In a great collaboration with Hummer Lab and the Kräusslich lab, Jan Philipp Kreysing, Maziar Heidari, Vojtech Zila and others tackle what happens when HIV capsid goes through an NPC. Instead of the NPC cracking the capsid, the capsid appears to crack the NPC (@MPIbp CIID_Heidelberg).

Our team’s latest research on IDRs in membrane remodeling. #membraneremodeling #ERphagy Hummer Lab Dikic lab

Heartfelt congrats to our group leader Eugene Kim (@EKimlab) on receiving the Heinz Maier-Leibnitz Prize, one of the most important awards for early-career researchers, for her research on genome packaging! #biophysics DFG public | @[email protected] Max Planck Society
👉 biophys.mpg.de/eugene-kim-hei…

Full article here: nature.com/articles/s4158…

Thanks for a truly fantastic collaboration to Alex Johnson, megan m, Nora McNamara-Bordewick, Hummer Lab, and Philip Kranzusch! SFB1507 Max Planck Institute of Biophysics Dana-Farber

#ATP , the energy currency of cells, is produced by the mitochondrial protein ATP synthase. Our Hummer Lab provides new insights into the structural mechanism and energetics of the crucial proton-driven c-ring rotation by atomistic free energy calculations👉pnas.org/doi/10.1073/pn…

a true adventure and privilege to work Danny's team and colleagues (cryoEM, MS, SAXS) IBC Academia Sinica danny hsu 中央研究院 Academia Sinica Khoo KH Tzu-Jing Yang SKCM2_Hiroshima Univ Karen big MD from Hummer Lab @[email protected] Sören von Bülow enhanced sampling from Isabell Louise Grothaus Hybrid Materials Interfaces and amazing Vidhi✨🧠🌱🦠️

🚨Now in print!🚨Sankalp Shukla @Sankalp Shukla_ in collaboration with Phyllis Hanson lab and Hummer Lab probes the mechanistic and cellular implications of direct membrane binding by the ESCRT and ERES associated Ca2+- sensor ALG- 2 protein. Read it: pnas.org/doi/10.1073/pn… PNASNews

Video by S. Rao: All-atom molecular dynamics simulation of the membrane-recruited ATG12-ATG5-ATG16L1-WIPI2 complex loaded with the ATG3-LC3 conjugate.
Congratulations to all authors from Michael Lazarou, Hurley Lab and Hummer Lab on this amazing publication in Science Advances!

S.Rao from our Hummer Lab & coworkers resolve mechanism of LC3 delivery to the phagophore membrane, a key step in selective #autophagy , by combining #MDsimulations & experiments. Three-step targeting of ATG12-ATG5-ATG16L1 machinery leads to LC3 lipidation👉science.org/doi/10.1126/sc…

Cross-country skiing with Hummer Lab. What a great day!

Scientists from the MPI of Molecular Physiology (MPI Dortmund) and from our Department of Theoretical #Biophysics (@HummerLab) have identifed a region in actin that functions as a “molecular backdoor” for phosphate to exit through!
👉 biophys.mpg.de/2768357/throug…

Very excited that our manuscript is now online NatureStructMolBiol!

nature.com/articles/s4159…

We show how actin filaments release inorganic phosphate (Pi) through a “molecular backdoor” and demonstrate that the backdoor is distorted in a disease-linked actin variant.

A thread (1/17)

New preprint! Zeke Cook’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!

The 2024 Gordon Conference on Autophagy will be held at the beautiful Il Ciocco site in Tuscany Mar. 10-15. If you have a passion for autophagy or just want to learn more, apply now before it gets oversubscribed! tinyurl.com/mu9dmc6w

Detection of various complexes in cryo electron tomograms. Great work by Sergio Cruz-León and others now online. Max Planck Institute of Biophysics #teamtomo #cryoem Chan Zuckerberg Initiative

The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, Amsterdam Institute for Life and Environment, @UGent, University of Kent solved the riddle: CydDC is a heme transporter👉biophys.mpg.de/cyddc
#biophysics #cryoEM

So nice to see Gerhard Hummer Lab in Okazaki!

New bioRxiv by Shanlin Rao Hummer Lab and co-authors from Hurley Lab Michael Lazarou for the collaborative work elucidating the mechansisms of LC3 targeting to membranes by the autophagy machinery Aligning Science Across Parkinson’s michaeljfox.org biorxiv.org/content/10.110…

Warmest congratulations to our SCALE@Uni-Frankfurt PI Bonnie Murphy on the prestigious Heinz #MaierLeibnitz Prize. Bonnies incredible work allowed her to solve the structures and mechanisms of enzyme complexes essential for CO2 fixation #StructuralBiology #climateChange Max Planck Institute of Biophysics

Common unwrapping schemes for NPT MD trajectories can mess up diffusion coefficients.
Congrats to Jakob Bullerjahn Sören von Bülow Maziar Heidari Jérôme Hénin for showing how to unwrap properly by staying off-lattice: doi.org/10.1021/acs.jc…