Join us next Tuesday from 12-1 at UMB for another Baltimore Brain Series seminar! Awardees Dr. Tarun Madangopal (Rajtarun Madangopal) and Dr. Maira Bicca (@bicca_maira) will present their work. Zoom link can be provided upon request! Univ of Maryland School of Medicine Neuroscience UM-MIND

Immune drivers of physiological and pathological pain. A new Perspective from Aakanksha Jain (Aakanksha Jain), Sara Hakim (@sarainthelab), and Clifford J. Woolf Boston Children's: hubs.la/Q02sSn0j0

#InnateImmunity #inflammation #Neuroscience #Neuroinflammation

New Johns Hopkins Medicine JHUSleep&PainLab study in Science Translational Medicine suggests sleep fragmentation could be a preclinical marker of spontaneous pain and contribute to poor sleep quality in patients with #ChronicPain bit.ly/3UnOH7m

Don't miss this week's issue of #ScienceTranslationalMedicine !

A #DeepLearning platform doubles detection rates for early-stage esophageal #cancer , a large clinical study helps answer why #COVID19 is more severe in older adults, and more. scim.ag/6Dj

An unbiased primary sensory neuron screen identifies the chemotherapeutic agent bortezomib as a potent TRPV1 sensitizer. Such long-term sensitization could lead to axonal death and sensory loss, a major symptom of bortezomib-induced neuropathy.
nature.com/articles/s4200…

JHUSleep&PainLab

First-in-human prediction of chronic #pain state in individuals with refractory neuropathic pain using chronic intracranial electrodes implanted in ACC and OFC

New from ShirvalkarLab UCSF @ChangLabUCSF et al.

nature.com/articles/s4159…

NIH - US cases of #ChronicPain outnumber those for diabetes, depression, and high blood pressure!

Human genetic and preclinical studies highlight the benefit of #BH4 inhibition.

Important to keep the inhibition in the periphery.

Why? And How?
👇
frontiersin.org/articles/10.33…

twitter.com/FrontPharmacol…

Happy to share our second preprint of the year… we show that increased #BH4 in #dopamine -producing neurons protects mice, primary cells from individuals with #Parkinson ’s disease (PD) and human midbrain-like #organoids from PD stressors……

biorxiv.org/content/early/…

New Research: Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy #pharmacology frontiersin.org/articles/10.33…

The parabrachial nucleus–anterior nucleus basalis–somatosensory cortex pathway during #sleep is critical for the generation and maintenance of chronic #pain

nature.com/articles/s4159…

Effect of Sleep Loss on Pain

Effect of sleep loss on pain—New conceptual and mechanistic avenues frontiersin.org/articles/10.33…

Nature research paper: Evolution of immune genes is associated with the Black Death go.nature.com/3ePVy7w

Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing | Journal of Applied Physiology journals.physiology.org/doi/abs/10.115…

Optimizing and Accelerating the Development of Precision Pain Treatmen... sciencedirect.com/science/articl…

Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer science.org/doi/10.1126/sc…