love to play op too slow with the automatic soap dispenser

GuideScan2 is available and ready to use for gRNA design and analysis, both command line tool and web interface. Read about it here: biorxiv.org/content/10.110…

Congrats to Roshni Patel for a successful PhD defense! Roshni is an amazing scientist, leader, and advocate for #ethics in the field of #genetics . So happy for her! 🎉

An Analysis presents a collection of non-coding CRISPRi screens from the ENCODE4 Functional Characterization Centers and establishes experimental guidelines for future screens identifying cis-regulatory elements. Steve Reilly
nature.com/articles/s4159…

Congratulations to the newest class of the Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN)! The 75 talented undergrads will gain hands-on research experience under the mentorship of early career scientists incl. grad students & postdocs. simonsfoundation.org/2023/09/26/sim…

Awesome new preprints finally shedding light on “that other protein” ZNF143 that was (supposedly) found at loop anchors. Great detective work

We previously reported the synZiFTR toolkit (compact synthetic ZF regulators) for engineering “clinically-optimized” gene circuits to control therapeutic human cell function
science.org/doi/10.1126/sc…

FUN UPDATE: We have a synZiFTR2.0 with enhanced activity (coming soon) ... 1/n

What if you could recombine any two DNA sequences in a programmable manner? We discovered an RNA-guided recombinase that can do just that! So happy to have co-led this project with Nicholas Perry

Gene Therapy Allows an 11-Year-Old Boy to Hear for the First Time

nytimes.com/2024/01/23/hea…

From SASP to GDF11 and TIMP2,circulating plasma proteins play big role in both aging and rejuvenation. However, we don't yet have ways to profile targets of these factors and how they get altered in aging. Josh Tycko Michael E. Greenberg are developing tools to profile these changes in vivo

Deprecated Methods convention: when a paper only reports the primers used to amplify a new insert they cloned into a plasmid, instead of simply providing the sequence of their new plasmid.

happened to us this week

In landmark decision, NIH awards $9 million for #Indigenous #Tribal Data Repository (RADx TDR) led by Native research institute to improve health in Indian Country.
Read and please share #Press release: zenodo.org/records/102403…
Health Disparities Stanford Medicine Stanford Health Care National Congress of American Indians

A fascinating fact I learned from Vijay Sankaran on a recent chat. By now, most of you might've heard about the UK's regulatory approval of the world's first CRISPR-based medicine (Casgevy) for the treatment of sickle cell anemia and beta-thalassemia (statnews.com/2023/11/16/u-k…). The…

How much does BCL11a repressor knockdown affect the global transcriptome (beyond the on-target HbF?)?

Rightly there's a lot of emphasis on genomic off targets. Did UK also define an 'acceptable' level of transcriptomic off targets?

I am excited and a bit overwhelmed with emotion at the news of the approval of CASGEVY in the UK. Going from the lab to an approved #CRISPR therapy in just 11 years is a truly remarkable achievement. (1/3)