Local T cell neighbourhoods determine outcome in non-small cell lung cancer treatment with KRAS-G12C inhibitors.

Timely and relevant work from Megan Cole and Panayiotis Anastasiou from the @JulianDownwardlab, and Claudia Lee from the Swanton Lab.
doi.org/10.1101/2024.0…

Fantastic talk at #AACR24 from Miriam Molina Arcas about novel approaches to tackling KRAS drug resistance in lung cancer. Great credit to Mona Tomaschko for her beautiful work.

Delighted to share our review on the impact of oncogenic KRAS on the tumour immune microenvironment and the potential for combining KRAS inhibitory drugs with immunotherapies. Cancer Cell #OpenAccess The Crick Miriam Molina Arcas authors.elsevier.com/sd/article/S15…

Happy to share our review published in Cancer Cell. We provide an update on RAS inhibitor development, discuss the rationale for combining #KRAS inhibitors with immunotherapies, and address challenges and future directions. Julian Downward The Crick eur03.safelinks.protection.outlook.com/?url=https%3A%…

Many congratulations to Charlie Swanton - for transforming the way we think about cancer evolution!

Cancer immune checkpoint blockade tends to be ineffective in tumours with an immune excluded microenvironment. In a new preprint from our lab we show how to make these cold lung tumours responsive to immunotherapy by targeting KRAS and SHP2.
biorxiv.org/content/10.110…

Congratulations to Rami Aqeilan and to the Cyprus Cancer Research Institute! Looking forward to fantastic developments at #CCRI

Fantastic PhD programme positions open at the Francis Crick Institute, including one in my lab.

Fantastic news that the UK is finally associated with Horizon Europe! This is a big step towards repairing the damage done to UK science and technology by the 2016 referendum and its chaotic aftermath. Relief that some sense has prevailed at last.

Just out in Clinical Cancer Research - our review on the challenges of combining immunotherapies with KRAS targeted drugs. doi.org/10.1158/1078-0…

Delighted to share a preprint of our latest work on a new immune visible GEMM of lung cancer - 6 years of hard work from Sarah Laing and a lot of help from many colleagues
biorxiv.org/content/10.110…

Mood music around UK and #HorizonEurope not good, according to Lisa O'Carroll The Guardian

Please note, Rishi Sunak and Michelle Donelan MP, it's dispiriting to those of us trying to maintain international momentum in UK science

theguardian.com/science/2023/j…

The government’s strategy to make the UK a global micropower!

'Renault and Aston Martin backer Geely to launch UK firm injecting £6bn and creating 19,000 jobs'

Gosh, doesn't that sound great? Tory MPs and the RW press have been feasting on the story.

Pity it's not true.

Let's take this step by step...

1/12
cityam.com/renault-and-as…

Lisa Hutchinson gives a great perspective on the long struggle to target RAS mutant cancers in the clinic. Not over yet!

Mike Waterfield was a giant in cancer biology. Kathy Weston’s excellent book tells the story beautifully and is a great (free) read. blueskiesbenchspace.org/index.php?pag=5

Very sorry to hear that Mike Waterfield died last week, aged 82. Mike's work on growth factors and PI 3-kinase was transformational and led to the development of enormously important cancer therapies. Enormously proud to have worked with him. crick.ac.uk/research/labs/…

A great privilege to attend the official opening of the Cyprus Cancer Research Institute today by the President of Cyprus, Nikos Christodoulides. A fantastic building to do great science in, surrounded by beautiful gardens! Dedicated to the memory of Nicola David-Pinedo.

We are recruiting six post-doctoral fellows as part of the AZ-Crick-Imperial College Molecular Glue Discovery Partnership. Apply by 31 May. crick.ac.uk/careers-study/…

The Francis Crick Institute, AsraZeneca and Imperial College launch an £11.2 million Prosperity Partnership on the development of molecular glues to tackle ‘undruggable’ disease targets. Look out for new research positions available. crick.ac.uk/news/2023-05-2…