Some of us might take issue with characterizing it as “pretty solid”. I actually wrote an entire book unpacking the evidence and while there were a few sticks left standing here and there, the evidence in support of the current biomarkers came away looking flimsy at best.

Well, here we go. Fasten your seatbelts. This is going to be a rough ride.

We agree. I made the tau comment mostly because I worry about the fuzzy way we define AD (made even worse by Jacks presentation at #AAIC23 ). We are quick to ascribe causality to correlation and need to be more careful.

Help me out here. If AD is defined by amyloid then you can’t have *any* stage of the disease without amyloid. Mutations in Mapt show that you can have tau-driven dementia. But these dementias are not AD by definition. So isn’t this a bit of circular logic?

Thank you

Poster is online. Feel free to download.

Only a few hours left to see one of the best posters at #AAIC . Oligodendrocytes rule!!4

Is there an FDA-approved drug to maintain mental function in Alzheimer's? I see this tweet from FDA (pic) and did a double take to ask this question.
Where I'm coming from I know the recent beta-amyloid drugs are still pending clinical outcomes. I thought at most you could say

Lon S. Schneider, MD Karl Herrup Tbf, this is getting way more exciting than science! I'll be there for the drama 🍿🍿🍿

Lecanemab is neither safe nor effective for Alzheimer's patients: Against the FDA approval - Sign the Petition! chng.it/bKSSzkD2 via Change.org

In my opinion we are going down a dangerous road. We need to consult our maps and re-orient ourselves. Please consider signing.

Ooops

Make mine a Talisker

1/n Thoughts on Neurofilament Light (NfL) as a neurodegeneration biomarker. I expect to hear a lot on it in the upcoming #Tofersen Adcom. U.S. FDA refers to it as a promising biomarker of neurodegeneration in several diseases at the Relyvrio #ALS approval👇Robert Howard Ash Paul

The point of this montage was not to suggest facial features can be used as a 'clock'. My point was we are sensitive to age as a 'feature' of someone. I gave only 6 ages as options; that constrains the response. Looking only at one panel, estimates could reasonably vary by ±20%