Our new chapter on glutamate signaling and imaging! w Abhi Aggarwal Kaspar Podgorski Joyce 佳欣 Amelia Waring, Adrian Negrean, & Jonathan Marvin

Protkit - the open source Python library for protein engineering
github.com/silicogenesis/…

Fast, simple, extensible, scalable, open.

Institute for Protein Design Heilshorn Lab Chang Liu PlessLab Colin Jackson Roberto Chica Lab LoogerLab

We worked with the community to design a new type of grantmaking program, and the first results are super exciting! 💚

This is so awesome!!! so happy to be part of this big push in the nascent field of climate biotech. and totally open review process. check out our 1st round of grantees and their awesome ideas!!!!

'Many commercial antibodies did not perform as expected — 60 percent of the antibodies were not specific to their intended target.'

Great article on antibody specificity and what this group are doing about it 👏 thetransmitter.org/open-neuroscie…

In an argument that appeared to flabbergast a small claims adjudicator in B.C., Air Canada attempted to distance itself from its own chatbot's bad advice by claiming the online tool was 'a separate legal entity that is responsible for its own actions.' cbc.ca/news/canada/br… .

2 raccoons trying to open a door

Gram positive

The evidence to date supports the hypothesis that SARS-CoV-2 emerged via zoonotic spillover at the Huanan Market.

But if you're confused about what scientists actually think, I highly recommend this thread explaining why dismissing evidence-based consensus undermines science.

This 2-week bootcamp course HHMI | Janelia will demonstrate how biological questions drive experimental designs across #microscopy platforms + #imaging scales

🔬Special lectures + didactic instruction + hands-on lab sessions

Apply by Feb. 15 @ bit.ly/OIBC24

HHMI NEWS

Amazing collaboration w/ Keisuke Yonehara & Akihiro Matsumoto. They got amazing imaging of GABA in amacrine cells w/ Janelia GENIE 's iGABASnFR2. So exciting to see this sensor produce some fascinating biology.

I 'm very excited to share our new work! By 2p GABA imaging with new iGABASnFR2 sensor developed by Janelia GENIE , we identified more than 40 functional GABAergic amacrine cell types in the mouse retina.
biorxiv.org/content/10.110…

ラボからの新しい仕事です。新しいGABAセンサーであるiGABASnFR2を用いてマウス網膜内網状層から２光子子GABAイメージングを行い、40以上のGABA作動性アマクリン細胞が存在することを突き止めました。
biorxiv.org/content/10.110…

Really fun collaboration! Oddly enough, Jonathan & I worked on chemotaxis Back in the Day, nice to circle back to it!

is the standard chemotaxis model wrong?

new paper from the lab by Trung Phan, Henry Mattingly, with Lam Vo, Jonathan Marvin, LoogerLab. We use fluorescence imaging to study collectively migrating bacteria and develop an improved model. Check it out!

pnas.org/doi/10.1073/pn…

yet ANOTHER important paper about #AlphaFold and #foldswitching . She's definitely burning the candle at both ends. Check it out! Important reminder for humility about how hard the many protein-folding problems are. But yes, enormous progress made recently & in the works!

🧠 I'm intrigued by GABA and inhibitory transmission, but to facilitate communication between neurons, an excitatory neurotransmitter - Glutamate - is essential. The recent surge in all-optical investigations of brain function has led to the development of fluorescent probes for…

Another important preprint about what #AlphaFold knows and doesn't know about protein folding, particularly fold switching, where a single sequence assumes two well-folded, very different structures. Check it out!

A feeding electric eel can cause transfection of plasmids from the surrounding environment into nearby organisms - natural, eel induced, electroporation.

peerj.com/articles/16596/