📢 Specific pairs of TADs megabases apart come together in fly neurons to enable the longest-range regulatory interactions described to date.

Summary in the thread 👇

Ecstatic to announce our latest project characterizing the continuum of regulatory and expression changes across the first 20 hours of Drosophila embryonic development! 🧵1/n science.org/doi/10.1126/sc…

HFSP Long-Term Fellow Michal Levo Princeton University and colleagues demonstrate that distant genes, separated by large genomic distances, engage in coordinated gene activity in living embryos bit.ly/3GF74My

Thank you @FacultyOpinions reviewers for highlighting our work!

facultyopinions.com/prime/74155828…

science.org/doi/10.1126/sc…

science.org/doi/10.1126/sc…
Science Advances Beautiful work by Anjali Kaushal and our wonderful collaborators Université de Lausanne Erez Lieberman Aiden with whom we are lucky to work

How does a skin cell become melanoma? We built one to find out, to help understand this lethal disease. science.org/doi/10.1126/sc… Science Magazine W/ co-1st Elena Torlai T, John Kwon, & senior author Aviv Regev. Early years joint w/ Levi A. Garraway. And many others in last tweet! 🧵 1/18

(1/6) our preprint biorxiv.org/content/10.110… is now out in Science Magazine science.org/doi/10.1126/sc…

Using super-res live-imaging we show that CTCF/cohesin loops are dynamic (~10-30 min median lifetime), rare (~3-6.5% looped fraction), and we fully parameterize a TAD.

Our enhancer mobilization paper is now online @nature!
nature.com/articles/s4158…
The effect of an enhancer depends on its genomic distance from the promoter through a nonlinear relationship with their contact probabilities, likely mediated by transient physical interactions.
A 🧵:

Thrilled to share our latest work, now in Science Magazine! Exploring how #3DGenome organization controls #transcription dynamics during #development . A few highlights below! #InHoxWeTrust
Xinyang Bing
Zachary Sisco
João Raimundo
Michal Levo
Mike Levine
science.org/doi/10.1126/sc…

I am very excited to announce that I am opening my lab for systems tissue pathology at Weizmann Institute ! We will use multiplexed imaging and AI to interrogate tumor-immune interactions and the tumor microenvironment, and... we are recruiting! weizmann.ac.il/mcb/Keren/

Our Crohn's disease scRNA-seq paper is online! We report on a cellular module comprising of immune & stromal cells enriched in patients resistant to anti-TNF therapy.
With Jerome Martin Miriam Merad, MD, PhD Judy Cho and a fantastic team at Lipschultz Precision Immunology Institute Mount Sinai Genetics Icahn School of Medicine at Mount Sinai

Our new paper is out! Dissecting viral circuits using an engineered virus, time-lapse microscopy and mathematical modeling.
pnas.org/content/early/…

Dynamic interplay between enhancer–promoter topology and gene activity (Chen et al.) go.nature.com/2LuAS4k