Congratulations to Pavel Mykhailiuk, DSc, on being awarded the Liebig Lecturer 2024 for his outstanding contributions to organic chemistry!

Further details on lecture series will be published on bit.ly/3UvOjUc

Aromatic methyl sulfones are popular (>30 drugs). Heteroaromatic ones are not (lack of approaches). Not anymore!
A new reagent towards methyl sulfones in one step!
Today in ChemRxiv bit.ly/3W0nWqA

I may not be the biggest fan of 111/BCPs but this new ChemRxiv from Enamine Ltd 🇺🇦 🇺🇦 and Mykhailiuk Chem 🇺🇦 is excellent! Light activated functionalization but without photocatalyst - scalable too thanks to flow! And the scope...wow!!
chemrxiv.org/engage/chemrxi…

Rapid functionalization of alkenes by in situ-generated difluoromethyl nitrile oxide. Published in J Org Chem/Org Lett :
pubs.acs.org/doi/10.1021/ac…

In 2020, we reported on O-[2.1.1]s (bit.ly/3Iwtt0j), and these cores immediately skyrocketed in medchem. Today, we disclose a full story on their synthesis, characterization, and validation as benzene bioisosteres. Published in Angewandte Chemie : bit.ly/4a49t0C

The craziest molecule I’ve seen recently: Enamine Ltd 🇺🇦 Mykhailiuk Chem 🇺🇦 ‘s group chemists push the boundaries of organic synthesis literally every day. Such molecules are known to have strong “W”-like ⁴J(H-H). In this case it is ~9 Hz.
#pharma #drugdiscovery #nmrchat

Pauson-Khand reaction with triplet nitrenes instead of CO via relay of triplet reactivity. Synthesis, computations, flow & MedChem. science.org/doi/10.1126/sc… Very excited about this wonderful team effort Fang Li 李方 Wenxin Felix Zhu ClaireEmpel @27_03_2022 Mykhailiuk Chem 🇺🇦 Proschak Lab

A SUPER FAST one-step synthesis of borylated cyclobutanes on scale!
Now, in Chemical Science: rsc.li/49aee8D

We love to increase the repertoire of saturated benzene bioisosteres for medchemists! Today in Angewandte Chemie: bit.ly/3SrPovh

Very very soon.

Magic has won over chemistry.

The molecular motif 1-azaspiro[3.3]heptane can behave like a mimic of piperidine, a popular heterocycle in many drugs. Until now, however, this molecular motif has been tough to make. cen.acs.org/synthesis/pipe…

Molecule of the week EN300-45606770
More details: bit.ly/49ycHdA

#Enamine #molecule #chemistry #science #drugdiscovery

Since 2014, the Baran group introduced aliphatic sulfinates as versatile reagents for direct cross-coupling with heterocyclic scaffolds. Our chemists have mastered the synthesis of these advanced reagents and hoarded 76 alkyl sulfinates in our stock: bit.ly/47gg1b1

Molecule of the week EN300-46134561
More details: bit.ly/3FG6uOH

#Enamine #molecule #chemistry #science #drugdiscovery

1,2-Disubstituted bicyclo[2.1.1]hexanes as mimetics for the ortho-Benzene!
rsc.li/494reNT Chemical Science