1/7 Our work online today, showing that targeted desialylation enhances the efficacy of bispecific T-cell engager (BiTE) for treating solid tumors #glycotime rdcu.be/dGnDG

Huge congrats to my friend Mari!!

Antibody drug conjugates (ADCs) are all the rage, for good reason.

They're generating stellar efficacy results in clinic, though they're not perfect.

I looked through 40+ ADC companies founded after 2010 to see what each was trying to improve on and with what new approach. ⬇️

So proud to see former postdoc ⁦Nick Riley⁩ ⁦University of Washington⁩ and current postdoc ⁦David S. Roberts⁩ receiving awards from ⁦Am Soc for Mass Spec⁩. Congratulations 🎉
asms.org/about-asms-awa…

Glad to see our work on Genetically Encoded LYTACs (GELYTACs) in PNASNews. Highlights include directed evolution of GELYTACs & secretion of GELYTACs by primary T-cells. Special thanks to Alice Ting Carolyn Bertozzi, and collaborators @mackalllab. pnas.org/doi/10.1073/pn…

Excited that our work has been published in J. Am. Chem. Soc.!

Excited to see our worked on PGL metabolic labeling published in ACS Chem Bio! Thank you to all our collaborators and my postdoctoral advisor Carolyn Bertozzi
pubs.acs.org/doi/10.1021/ac…

New review from Lina Petersone & I highlights recent findings on IL-21 and germinal center biology. Such an interesting cytokine!

dx.doi.org/10.1093/intimm…

Our new review on the Immunology of #Type1Diabetes now out in Nature Rev Immunol – really important area for understanding and maximising immunotherapies. Kevan Herold Todd M. Brusko Thomas Delong, Ana Luisa Perdigoto, Noah Biru Diabetes UK Research JDRF UK IIT
nature.com/articles/s4157…

A nice early Christmas present! Delighted to have contributed in a small way to this work - great stuff by Vijay Chudasama Baker Group and a very talented bunch of co-workers.

Thrilled to share my first preprint! TICTACs highlight the modularity of antibody-carbohydrate conjugates and their potential to act as highly tumor-specific immunotherapies. Shoutout to my collaborator Nick Till, and thank you Carolyn for your support!

Congratulations ⁦⁦Lindsay Guzmán⁩ on this preprint describing a new approach to image PGL, a virulence-associated mycobacterial lipid. Great collaboration with the Branch Moody and ⁦⁦Michael Shiloh, MD, PhD⁩ labs biorxiv.org/content/10.110…

Congratulations Jonathan Yang, preprint on project co-led by ⁦Alice Ting⁩, featuring collaborators ⁦⁦Mackall Lab⁩. Genetically-encoded LYTACs (GELYTACs) developed w/directed evolution, T cells engineered to secrete them for cancer Tx. biorxiv.org/content/10.110…

Huge congratulations to Léa Rochet on her work on the use of pyridazinediones for tuneable & reversible covalent cysteine modification, a highly collaborative project with Baker Group Mike Porter Kreso Bucar Molly Stevens & Abil Aliev, plus many more! pubs.rsc.org/en/content/art…

We are searching for our next Institute Scholar Sarafan ChEM-H, spread the word!

facultypositions.stanford.edu/en-us/job/4945…

Very happy to share a preprint exploring the benefits of site-selective conjugation for generating affinity protein–oligonucleotide conjugates. Many thanks to all involved! Peter Szijj @VijayChudasama deMello Group Ioanna Thanasi

doi.org/10.26434/chemr…

A new opportunity to work with us as a post-doc, in a collaboration with the Baker Group, on investigating new biorthogonal reactions via untapped modes of reactivity. Link below: jobs.ac.uk/job/DBM562/res…

📢Exciting new PDRA opportunity to join the Baker Group and investigate new biorthogonal reactions via untapped modes of reactivity. Further information linked below. Deadline 16/08/23. 🥼

jobs.ac.uk/job/DBM562/res…

Researchers Peter Szijj , Vijay Chudasama , our director & Nobel laureate Carolyn Bertozzi & team used click chemistry to quickly build a three-component therapy to combat #cancer : bit.ly/3KkCEC6