Laughing all the way to the GMC, yes.

We’re happy to be involved with Mediaplanet UKIE on the Sleep & Wellness campaign, launching in the Guardian and online. Follow the link to read more 👇 tinyurl.com/mr3ffcum #SleepHealth2024 #WorldSleepDay

Consultant BMA members:
The referendum for the pay deal has reached your inboxes. In the last ballot 38% of us didn’t bother voting for something that will affect the rest of our lives. Don’t be that person.

Simply search your overflowing inbox for the email circled, then…

Asians have more side effects to antidepressants.

On reason: 20-40% metabolize them slower in the liver.

Desvenlafaxine (Pristiq) isn't metabolized there, which may explain why it was better tolerated than duloxetine (Cymbalta) in this large 2023 trial from China:…

VERY pleased to see the results of MENTOR (a new employee-manager joint intervention that improves psychological flexibility, interpersonal relationships, & engagement) published in JCBS😍Steven Marwaha Mind Prof. Holly Blake Louise Thomson et al.

linkinghub.elsevier.com/retrieve/pii/S… 1/

A sleep-circadian pathway to mood disorders is an attractive hypothesis needing data from prospective, mechanistic & interventional studies

Grateful for support (Wellcome NHMRC) to test key hypotheses

Ian Hickie Sean W Cain Prof Miranda Wolpert

onlinelibrary.wiley.com/doi/10.1002/wp…

Our heliosbd.com study is now open for volunteers from across Scotland. We're looking for people with #bipolardisorder AND people without any mental health problems (as controls) 👇

📢NEW PAPER📢: interplay between polygenic risk for mood disorders & life events in #bipolardisorder
📊Sig correlations between PRS-MDD & life events before worst depressive episode, nom sig result for PRS-BD.
Clement Zai Kennedy Lab SGDP Centre KCL
tinyurl.com/ynsu973v

Should be a core responsibility of all clinical academics. Not always a comfortable or popular activity.

Hour 5 in mandatory face to face teaching hearing about a digital mental health app that will never work, but will make lots of money for a dude called Tarquin and fill the Trust emails for the next three weeks.

Sleep and circadian rhythm (SCRD) disturbances: plausible pathways to major mental disorders? pubmed.ncbi.nlm.nih.gov/38214638/ Testing causal paths to onset & course, and evaluating treatments, is now a high priority - notably for early-onset mood disorders Prof Miranda Wolpert Niall Boyce

Eye-opening study on clinical prediction failures using ML when training and test sets are different

science.org/doi/10.1126/sc…

How to define treatment resistance in anxiety disorders? Our Delphi method-based consensus is out now in World Psychiatry.

Led by Katharina Domschke and David Baldwin (David Baldwin) via the ECNPtweets Anxiety Disorders Research Network

onlinelibrary.wiley.com/doi/10.1002/wp…

Clinical research fellow post with Prof Oliver Howes and me..develop expertise in use of clozapine and clinical research in ppl w FEP. Opportunity to get a taste for clinical research.

The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data

50 day free full text link:
authors.elsevier.com/c/1iMuDbXYirEMT

A hypothesis directed study of neurostimulation in depression... should they all be structured like this?

Targeted neurostimulation reverses a spatiotemporal biomarker of treatment-resistant depression | PNAS pnas.org/doi/10.1073/pn…

So true 🤣 #newyear2024

Congratulations to our Project Director Dr Ed Day for making the New Year Honours list Dr Ed Day MBE 🙌
Ed has worked tirelessly for decades to improve the lives of some of society’s most vulnerable. Ed is much loved in UK Recovery for his commitment to our community and concepts

Merry Christmas to my fellow clinical trialists around the world!

May your holiday season have zero SAEs and your new year filled with p-values less than 0.05 🎅

Here is my short summary of healthcare in 2023

1⃣Magnesium glycinate does not help in sleep or reduce depression. This was the same finding or lack thereof in the years 2022, 2021 and 2020. It will most probably the same in the coming years.

2⃣Detox was still a thing even in…