First time I am advertising my consulting, but I make diagrams and computationally reproducible R figures for research projects. If you want a custom diagram or figure, contact me at: [email protected]

Interesting study looking at how common education polygenic scores modify the effect of rare developmental delay genes. Given that the EA PGS is actually 2/3rds dynastic environment (or stratification), this suggests that environment could be a substantial compensatory force.

I had two postdoc mentors bail from the grant-funded science career. One to Big Pharma due to desire to be closer to helping people with health problems. One to NIH Program, presumably due to being exhausted from the grant chase.

6/ A significant and clinically meaningful OS benefit was observed with adjuvant pembro vs placebo:

HR 0.62; 95% CI 0.44-0.87; P = 0.005

At 48 months: 91% of pts receiving pembro were still alive vs 86% with placebo (5% absolute benefit)

Happy to share my latest preprint from Nicholas Mancuso lab. We introduce SuShiE (Sum of Shared Single Effect) model to perform multi-ancestry SNP fine-mapping for molecular traits (e.g., mRNA and Protein). (1/n) medrxiv.org/content/10.110…

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

People say the gut microbiome is related to how you respond to food.

Our series of randomized N-of-1 trials will try to sort out individual responses from individuals' responsiveness in terms of postprandial glycemia.

Feedback welcome!

medrxiv.org/content/10.110…

'our analysis also found multiple significant interactions between PGS and vPGS, suggesting that the non-additive and GxE components related to PGSs could impact prediction accuracy'

Happy to share paper

Efficient storage and regression computation for population-scale genome sequencing studies

biorxiv.org/content/10.110…

'caQTLs and haQTLs capture regulatory variations not associated with eQTLs and explain ∼49% of the functionally annotated GWAS loci'

Been clear for a while that accessibility & histone marks provide more info for explaining & fine mapping GWAS loci than expression. 1/

💯 to this conclusion (and the rest of the piece). DIY microbiome hackers have an opportunity to demonstrate a more nimble clinical trial process and are instead choosing the path of wellness scams. But there's still time to change course.

Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning
nature.com/articles/s4159…

I discussed the data behind the recent anti-cavity Lumina treatment. TLDR: while the approach looks promising and self-experimentation is cool, most of the direct data comes from small studies in rats and well... most humans are not rats.

writingruxandrabio.com/p/on-lumina-an…

What's more, I…

New episode (928), with Dr. Charles Roseman (Charles Roseman): The #evolution of complex Traits, Hereditarianism, and understanding sex. #Anthropology #Biology #Science

YouTube: youtu.be/5Usuozf02xs
Podcast: bit.ly/4azHI0J

#GWAS can be affected by confounding; Alexander Strudwick Young explores a Carl Veller Graham Coop #PLOSBiology study which asks how different sources of confounding affect GWASs & whether family-based designs offer a solution. Primer plos.io/3UeYyfC Paper plos.io/3Qmu2hF

How did this large study debunk the spurious link of acetominophen/tylenol to autism? The same way that most spurious associations with behavioral traits get deubunked, with SIBLING CONTROLS!

'please listen closely as our menu items have recently changed' is a good example of how society has normalized corporate lying

Registration is now open for our 5-day Simons workshop taking place in two months (June 10th-14th) in Berkeley (w Aditi Krishnapriyan ).

AI≡Science: Strengthening the Bond Between the Sciences and Artificial Intelligence simons.berkeley.edu/workshops/aisc…