In a study supported by #PIDDN , Alex Doan, Kat Mueller, PhD, Andy Chen, Mackall Lab, Evan Weber, et al. showed that overexpressing FOXO1 increases the antitumor activity of #CARTcells in preclinical models nature nature.com/articles/s4158….

Congratulations on an absolute tour de force from Evan Weber Kat Mueller, PhD Alex Doan Andy Chen. So happy to see this out.

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs?

We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/

nature.com/articles/s4158…

This is fantastic news. So well deserved.

Hot off the press..Congrats to my co authors. Dr. Niketa Shah, Alex Ngwube and Shalini Shenoy.. where we delve into Mixed chimerism post HCT in SCD #bmtsm .. DM if you need a pdf of the paper ! .journals.lww.com/co-hematology/…

Thank you to the PearLab, R. Babak Faryabi lab, and Jordan lab for a great send off today. I know it was long overdue (by my fault..not theirs) as I started my new position this summer at CHOP. It was lovely to celebrate with you. Looking forward to awesome collaborations ahead!

Congrats on the amazing paper Jennifer E Wu. So nice to see this out there.

In vitro models of CD8 T cell exhaustion make high-throughput interrogation easy, but can they be used to discover real Tex biology with therapeutic relevance?

Read to find out! In our new work from the E. John Wherry lab, out now at Science Immunology, we...
bit.ly/45yOFMB

Thrilled to share our paper published today in Nature Cancer showing MHC-I-negative tumors remain susceptible to CD8+ T cell killing via NKG2D, challenging the notion that MHC-I loss is a resistance mechanism against T cell-dependent immunotherapy

nature.com/articles/s4301…

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Our work from the Jordan and PearLab is out in Cell Reports. Thanks to all who helped with this cool project looking at the role of Trib1 in regulating T cell exhaustion and effector states. E. John Wherry R. Babak Faryabi Oishi Bardhan Dr. Amy Baxter Dr. Josephine Giles

This is amazing Michael Triebwasser !!! What a great project and paper. Congrats all the way around, friend :)

Thanks for the shout-out Waggoner Lab :)

Dr. Caroline Diorio was recently featured in CEO Council discussing what it means to live and work in the life sciences in the greater Philadelphia area. Read more at: ms.spr.ly/6019gjXo9.

It is such a privilege to work with this amazing group in our Cell Therapy and Transplant Section, at Cancer Center @ CHOP and Penn Medicine, and with our terrific referring docs. 85% of our CAR T pts come from outside our area.
Looking forward to fast manufacturing!@NovartisCancer

Join us in recognizing a Children's Hospital milestone: CHOP treated its 500th patient with CAR T-cell #immunotherapy ! 11 years have passed since Emily Whitehead received the “living drug” pioneered by Penn & CHOP researchers. Today, she remains cancer free. ms.spr.ly/6014gAPwr

A conversation today…how do you say the transcription factor Eomes?? It seems that every lab I’ve been acquainted with does so differently.

Evan Weber Kat Mueller, PhD Oishi Bardhan Dr. Amy Baxter Edward Briercheck Dr. Josephine Giles

Excited to share our review article online Nature Reviews Molecular Cell Biology We discuss single-cell/spatial technologies enable multi-omics profiling and highlight their impact in cell lineage tracing, atlas production, and tumor immunology! Thanks to all the authors Rong Fan Rahul Satija Alev Baysoy

Studying human pediatric and mouse IgA deficiency, in collaboration with silverman lab, shows increasing exposure of commensal microbes to the systemic immune response yields immune dysregulation -- helping understand why only some IgA deficient patients are symptomatic!

The Leibowitz Lab is hiring! Our focus is to develop effective CAR T cell based therapies for pediatric solid tumors. We are seeking highly motivated lab technicians and post-docs.
cu.taleo.net/careersection/…

Calling all flow cytometry aficionados! There are some SERIOUSLY cool projects just waiting to get rolling on this shiny new sorter, and the team of researchers couldn't be better. Please share!