new article on biomarkers for aging research (Biomarkers of Aging Consortium ) in Schrödingers Katze

schroedingerskatze.at/bioramarker-pr…

Our paper introducing Pace of Aging as a measure for HRS (and sister surveys) won the best Paper award at PAA!! Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium #PAA2024

Presented @NIA Biomarker Meeting on generalizing Pace of Aging to Global Gateway of Aging studies, paper with Daniel Belsky
Columbia Aging Ctr Friends of NIA CPRC Biomarkers of Aging Consortium NIA Division of Behavioral and Social Research #PAA2024

Arun Balachandran (@arunabc3.bsky.social) Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium Congratulations!!

🧵 1/6 Greater insights into the hallmarks of aging and their links to diseases have sparked a surge in testing the geroscience hypothesis. This focuses on interventions to delay aging-related diseases, underlining the growing need for operational biomarkers of aging.

Arun Balachandran (@arunabc3.bsky.social) Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium Congrats

🧵 6/6 Check out the latest open-access editorial from Consortium Contributor Nathan LeBrasseur in Aging_Cell for high-level insights into where our field stands in relation to aging interventions and health outcomes based on biomarkers of aging. buff.ly/3vSHXF0

🧵 5/6 Biomarkers showing changes in aging-related proteins might also predict long-term health outcomes. This could make them valuable in both clinical trials and personal health management, aligning with the geroscience hypothesis.

Arun Balachandran (@arunabc3.bsky.social) Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium Hearty congratulations!! 🎉🎉🎉🎉

Biomarkers of Aging Consortium Nathan LeBrasseur Aging_Cell (2of2)
But pomegranates will boost mitophagy.
Regular physical exercise & stress reduction will also help to reduce it.
Oxidative stress is one driver of cellular senescence.
#CellularSenescence #Oxidativestress
#biology #mitophagy #biomarkers

🧵 3/6 A candidate panel for senescence biomarkers, including various proteins, shows promise. It can measure changes in the blood tied to aging and could potentially guide interventions targeting aging hallmarks.

Biomarkers of Aging Consortium Nathan LeBrasseur Aging_Cell (1of2)Vitamin & minerals in right doses can act as suppressors of senescence.
Senescent cells accumulate dysfunctional organelles so read about these interactions in cellular senescence.

Arun Balachandran (@arunabc3.bsky.social) Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium Beautiful charts😃

Arun Balachandran (@arunabc3.bsky.social) Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium Great, many congratulations 🎉

Arun Balachandran (@arunabc3.bsky.social) Daniel Belsky PAA Columbia Aging Ctr CPRC Biomarkers of Aging Consortium Congrats, Arun!

Daniel Belsky 🧵 5/5 For more insights, feel free to request access to the publication buff.ly/3UdiBLg

🧵 1/5 Recent work co-authored by Contributor @danbelsky reveals that biological aging markers measurable in our blood can directly link to brain structure changes. DunedinPACE measure demonstrates significant correlations with reductions in hippocampal and total brain volume.

🧵 2/6 Techniques for measuring aging hallmarks like mitochondrial dysfunction and proteostasis are advancing. Yet, some challenges remain in accessing tissues like the heart and brain for human studies, driving efforts to develop more accessible biomarkers.

Daniel Belsky 🧵 4/5 The research supports the geroscience hypothesis, proposing that a universal aging process affects all organ systems, including the brain. This insight helps track and potentially mitigate aging effects through early interventions.