Rare SH2B3 coding variants in #lupus patients impair B cell #tolerance and predispose to #autoimmunity , say Yaoyuan Zhang (Jim Yaoyuan Zhang), Rhiannon Morris, Grant Brown, Carola Vinuesa (@VinuesaLab), Julia Ellyard John Curtin School of Medical Research, ANU & colleagues: hubs.la/Q02mTRgX0

#LymphocyteBiology

Big congrats to Jim (Yaoyuan) Zhang Jim Yaoyuan Zhang, and Julia Ellyard, and thanks to many collaborators for helping elucidate the role of SH2B3 variants in breaching B cell tolerance and contributing to lupus. Great team effort! rupress.org/jem/article/22…

B cells also orchestrate tolerance of developing thymocytes… | Nature nature.com/articles/s4158…

Spectacular results of CAR-T cell therapy in lupus, myositis and systemic sclerosis… nejm.org/doi/full/10.10….)

Probably a “must watch”: No sympathy for striking doctors? Watch ITV’s Breathtaking and ask: have we paid our debt to them? theguardian.com/commentisfree/…

See also the recent paper in Science Magazine by Dai, Gu, Han, Carola Vinuesa, Shen, & al. that also identified #ZEB2 as key #TranscriptionFactor driving #age -associated #BCell ( #ABC ) development & function!

bit.ly/Sci_adf8531

This is going to be a fantastic meeting in beautiful Galway, thanks to the hard work of Michelle, Oliver and Rhodri, and an incredible list of speakers. Don’t miss it!

In Science Magazine this week: Dai Dai, Shuangshuang Gu, Xiaxia Han, Carola Vinuesa, Nan Shen, & al. report that the #TranscriptionFactor #ZEB2 regulates the development & function of #age -associated #BCells ( #ABCs )!

bit.ly/Sci_adf8531

A beautiful piece of work @sciencemagazine led by my wonderful and longstanding collaborator Nan Shen on the important role of ZEB2 for pathogenic B cells (ABCs) in lupus.

Tan merecido 👏👏👏👏

Celebrating Cynthia Turbull’s and Pablo Canete’s superb effort with this story out today.
DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency | Science Advances science.org/doi/10.1126/sc…

Un libro de ficción apasionante de mi hermana escritora: “Genes a la carta”. El prólogo: “El origen es una obsesión… en un futuro donde se edita la genética.. se borra el origen tradicional (el geográfico, el étnico, incluso la familia)..” da que pensar.. eolasediciones.es/catalogo/colec…

I’ve been trying to find a way to describe what its like to be facing the end of your life. While no singular description can do it justice, because of the complexity of the subject, here is my best attempt.

Most people unfortunately have experienced loss and grief. It may be…

Thanks to Merck for the superb award ceremony, and to Amy Kao EMD Serono, Anne Davidson Northwell Health,
Annemarie Sluijmers Lupus Europe, Christof Specker, Edward Vital Ed Vital BILAG and Lupus Forum and Jan Klatt, Merck Healthcare for their time & fantastic panel discussion.

A great recruitment by CSIRO

Thank you Claudine, another team effort. Hopefully genomic medicine and science will continue to help many other mothers of very sick children with rare genetic disorders that continue to be wrongly accused of killing or inflicting harm on their children.

The LRA honors the 2023 Lupus Insight Prize Recipient Carola Vinuesa, MD, PhD, of The Crick Institute for discovering a specific gene variant that causes lupus in some patients.

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This is the amazing work of a great team - thanking in particular Grant Brown, Vicki Athanasopoulos and Yuke He; my long term CPI collaborators; Matt Cook and Nan Shen. Plus all past & current lab members, patients like Gabriela and their families. Together we will get there!

Very thankful to be doing my PhD with an amazing mentor like Michelle! Always learning so much about doing science and leading a lab from her, and constantly in awe at how she manages all this with a 18-month old #wonderwoman #WomenInSTEM

Thank you Brian. It has given me and my team at ANU an enormous satisfaction to be able to do this work.