It’s raining microbes in Cell Host & Microbe! While April showers bring May flowers, the April issue of Cell Host & Microbe plants new seeds of information! Live now:
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Diurnal rhythmicity of infant fecal #microbiota . In randomized controlled trial, metabolite & bacterial profiling revealed 24h oscillations &circadian networks. Rhythmicity in bacterial diversity &functional pathways increased w/age
Haller lab TU München
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Infant gut microbes have their own circadian rhythm.

Read more in Cell Host & Microbe:
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TU München Dirk Haller

Insertion sequence-driven evolution of microbiota. Duerkop Lab Andrew Hryckowian & Kirsch develop pipeline that reveals presence, abundance & dynamics of IS insertions in human intestinal #microbiota and their roles in genome diversification & adaptation cell.com/cell-host-micr…

#workhardpartyhard A great team to celebrate our latest published paper on #Brucella reprogramming of host N-glycome Cell Host & Microbe Cirad INRAE Santé Animale authors.elsevier.com/c/1ipdA6t8JEqo4~

Brucella drives host N-glycome remodeling. Brucella effector Rhg1 reprograms host N-glycome to support its intracellular lifestyle via interacting with OST complex &ER SEC61 translocon to manipulate N-glycosylation & host functions cell.com/cell-host-micr…

Enterotype linked to ICB treatment outcomes. New work shows heightened #immunotherapy responsiveness in older individuals w/cancer. Aging-enriched #microbiome enterotype assoc w/improved outcomes & enterotype-derived FMT shows therapeutic potential in mice cell.com/cell-host-micr…

Online today in Cell Host & Microbe !!! Big achievement on #brucella new #effector that modulates host glycome for infection. Cirad INRAE INRAE Santé Animale University of Missouri Infectious Diseases

Opposing diet, #microbiome & metabolite mechanisms in IBD. Combo of genetics, reduced dietary fiber &mucin-degrading bacteria triggers IBD. Mucus loss promotes Th1 that drives #colitis . Fiber-free exclusive enteral nutrition prevents colitis Eric C Martens cell.com/cell-host-micr…

Happy to share our new manuscript Cell Host & Microbe about the biochemical action of plant MLKL proteins!!
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Sugarcoating colonization. Eliza Loo PalomaD &Frommer Heinrich-Heine-Universität Düsseldorf examine organization of #microbiota along longitudinal axis of #Arabidopsis root. SWEET transporters contribute to sugar distribution, which is req'd for spatial colonization of bacteria cell.com/cell-host-micr…

Sugar transporters spatially organize microbiota colonization along the longitudinal root axis of Arabidopsis Cell Host & Microbe
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Salmonella resists oxidative killing. #Salmonella anaerobically respires methionine sulfoxide produced as ROS byproduct of phagocytes, which supports synthesis of antioxidant H2S via IscS-mediated desulfuration of cysteine. Vazquez-Torres CU School of Medicine cell.com/cell-host-micr…

Fighting pneumococcal superinfection. xue liu Jean-Claude Sirard Jan-Willem Veening ID lafB as crucial for S.pneumoniae replication. Intranasal vaccination w/flagellin-adjuvanted LafB induces Th17 lymphocytes that protect against pneumococcal superinfections in mice cell.com/cell-host-micr…

Plant cellular messengers mobilized to defend. Sun & Zhang highlight works in Cell Host & Microbe Cell investigating DGK5-mediated phosphatidic acid in regulating ROS signaling and plant immunity
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PA-ROS interplay. Upon chitin treatment of plants, DGK5β is activated by S506 phosphorylation to produce phosphatidic acid, which binds the ROS-generating enzyme RBOHD & inhibits its vacuolar degradation, thereby promoting ROS production & #plant immunity cell.com/cell-host-micr…

Invade to evade: E. coli’s gutsy survival strategies. Mulla &Bollenbach Universität zu Köln highlight work of @Dr_ErdalToprak & Koh lab @UTSWNews showing that specific mutations allow E.coli to invade intestinal cells in mice, thereby evading #antibiotic treatment cell.com/cell-host-micr…

A hideout to escape antibiotics. @Dr_ErdalToprak & Koh lab @UTSWNews show E. coli colonizing murine GI tract evade #antibiotics by acquiring mutations increasing ability to invade & survive within intestinal cells, where antibiotic concentrations are lower cell.com/cell-host-micr…

Live #biotherapeutic decreases methionine. Engineered #probiotic E.coli Nissle can degrade methionine in GI tract, marking potential treatment for #homocystinuria . Resulting strain, SYNB1353, lowers plasma methionine in mice, NHPs & humans Synlogic cell.com/cell-host-micr…

A tough act to swallow: Streptococcus anginosus & #GastricCancer . Wong & Tan Duke-NUS Medical School highlight work of Jun Yu The Chinese University of Hong Kong - CUHK identifying Streptococcus anginosus, a #bacterium normally residing in the oral cavity, as a contributor to gastric carcinogenesis cell.com/cell-host-micr…