Orestis Katsamenis(@katsamenis) 's Twitter Profile Photo

📢 Our latest paper Davis Laundon etal) investigates evolutionary drivers of structural diversity in humans and equids. Using xrayhistology.org and EM, we uncover fascinating adaptations in equid villi for nutrient transfer.👇
doi.org/10.1098/rsbl.2…

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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Pleased to share our latest paper 'Convergently evolved placental villi show multiscale structural adaptations to differential placental invasiveness' in Royal Society Publishing out now! Southampton Medicine Biological Sciences University of Southampton News

royalsocietypublishing.org/doi/10.1098/rs…

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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Using the segmented EM data, we modelled diffusive processes within the bounds of actual tissue architecture and propose that these trophoblast protrusions decrease uptake distances and boost facilitated diffusion of nutrients such as amino acids in equids.

Using the segmented EM data, we modelled diffusive processes within the bounds of actual tissue architecture and propose that these trophoblast protrusions decrease uptake distances and boost facilitated diffusion of nutrients such as amino acids in equids.
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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Human & equid placental villi evolved independently and 'invade' maternal tissue to different degrees for nutrient uptake (humans - high, equids - low). Comparing the structure of these villi could help answer if placentas evolved adaptations to changes in nutrient availability.

Human & equid placental villi evolved independently and 'invade' maternal tissue to different degrees for nutrient uptake (humans - high, equids - low). Comparing the structure of these villi could help answer if placentas evolved adaptations to changes in nutrient availability.
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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Taken together, we propose the features we have observed in equid villi are adaptations that have evolved in response to low nutrient availability in less 'invasive' equid placentas, suggesting support for maternal-fetal conflict in placental evolution. Rohan Lewis Neil J Gostling

Taken together, we propose the features we have observed in equid villi are adaptations that have evolved in response to low nutrient availability in less 'invasive' equid placentas, suggesting support for maternal-fetal conflict in placental evolution. @r_m_lewis @NeilJGostling
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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Very pleased to be involved with this great new bioRxiv 'Evolutionary and biological mechanisms underpinning chitin degradation in aquatic fungi' lead by Dr Nathan Chrismas and Michael Cunliffe 🏳️‍🌈, out now on ! Dr. Kimberley Bird Dr. Poppy Hesketh-Best Chloe Lieng

biorxiv.org/content/10.110…

Very pleased to be involved with this great new @biorxivpreprint 'Evolutionary and biological mechanisms underpinning chitin degradation in aquatic fungi' lead by @CyanoEvo and @sea_bugs, out now on #DarwinDay! @Kimberley_EBird @PoppyBest3 @Chloe_Lieng 

biorxiv.org/content/10.110…
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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Using , we imaged in human and equid (horse, donkey, mule, wild horse, & zebra) placental villi and found that equids have a significantly larger surface area for any given volume (SA:V) for nutrient uptake than humans. μ-VIS X-ray Imaging Centre Orestis Katsamenis

Using #microCT, we imaged in #3D human and equid (horse, donkey, mule, wild horse, & zebra) placental villi and found that equids have a significantly larger surface area for any given volume (SA:V) for nutrient uptake than humans. @muVISxrayCT @katsamenis
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Rohan Lewis(@r_m_lewis) 's Twitter Profile Photo

I was excited to present work at IFPA from Davis Laundon in my lab showing the first quantitative comparison of human and equid placental villi and asking really fundamental questions about placental efficiency. If you weren't at IFPA, the paper is in preparation!

I was excited to present work at IFPA from @davislaundon in my lab showing the first quantitative comparison of human and equid placental villi and asking really fundamental questions about placental efficiency. If you weren't at IFPA, the paper is in preparation!
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Davis Laundon(@davislaundon) 's Twitter Profile Photo

We then took correlative sub-volumes for electron microscopy and found that equid villi display deep trophoblast protrusions surrounding blood vessels not seen in humans. BIU Southampton James Thompson Tricia Goggin

We then took correlative sub-volumes for #SBFSEM electron microscopy and found that equid villi display deep trophoblast protrusions surrounding blood vessels not seen in humans. @BIUSoton @jamesjt89 @triciagoggin
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Raquel Cruz, PhD.(@Raquel_DaCruz) 's Twitter Profile Photo

Check out this fascinating review. Placenta is a vital organ that plays a role in the transmission of epigenetic assays traits from parents to the offspring.

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Davis Laundon(@davislaundon) 's Twitter Profile Photo

Our latest review 'Placental evolution from a three-dimensional and multiscale structural perspective' was selected as the Editor's Choice article for January's issue of Evolution Journal! Check it out below 👇

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