#STROKE : Mendelian randomization study identifies a potentially causal role of lower LDL cholesterol on imaging biomarkers of small vessel disease. #AHAJournals ahajournals.org/doi/10.1161/ST… Dipender Gill Marie-Joe Dib

Happy to share our latest study, now published in JAHA. Our research provides genetic evidence supporting potentially causal associations between multiple proteins and adverse outcomes in human heart failure🫀Many thanks to everyone who contributed to this work!

New Mendelian Randomization from Loukas Zagkos Héléne (Toinét) Cronjé Benji Woolf Stephen Burgess Shuai Yuan Susanna Larsson Joanna Tzoulaki Dipender Gill et al.: Long-term increases in circulating #caffeine may reduce bodyweight and the risk of osteoarthrosis and osteoarthritis. shorturl.at/blySV

Our systematic inflammatory marker & cancer MR analysis now out in eBioMedicine – The Lancet Discovery Science. Thx to
daniela Ville Karhunen Niki Dimou Dipender Gill george davey smith Abbas Dehghan Kostas Tsilidis Richard Martin & many others ICEP
Imperial School of Public Health & to Cancer Research UK for funding
twtr.to/BdQtT

Our letter, together with Dipender Gill, is now online STOTEN, where we commented on some serious issues with MR design assessing the effect of air pollution.
pubmed.ncbi.nlm.nih.gov/38281648/
HKU Public Health HKU Medicine

There are considerable socioeconomic inequalities in pregnancy health. We find that intervening on targetable risk factors may reduce adverse pregnancy outcomes associated with low levels of education.

Yale School of Public Health Yale Chronic Disease Epidemiology Department Dipender Gill Zeyan Liew Xiaoting Shi Tom Ivar Lund Nilsen Stephen Burgess

Patient and public involvement
bmj.com/content/383/bm…

Does improving erectile function increase fertility?

New research led by Benji Woolf, Stephen Burgess & Dipender Gill

Read more 👇
mrc-bsu.cam.ac.uk/blog/does-impr…

Paper in The BMJ 👇
bmj.com/content/383/bm…

Cambridge University

New study supports the potential for PDE5 inhibition to increase the number of children fathered by male patients, but finds no evidence of such an effect in female patients Benji Woolf #ChristmasBMJ
bmj.com/content/383/bm…

Very excited to be leading the first practical of the 'Genetics in Drug Development' course MRC Biostatistics Unit Cambridge University 🧬💊Today we will be covering examples including IL-6⃣inhibitors and drugs in #AlzheimersDisease 🧠Dipender Gill Stephen Burgess Ville Karhunen Héléne (Toinét) Cronjé bit.ly/3uD6ddm

Can we precisely rewrite the genetic code - make a single DNA spelling change - in the liver of a human being for clinical effect?

YES!

Scientific milestone: VERVE-101 provides first proof-of-concept for in vivo DNA base editing in humans

Clinical implication: It’s early…

👇Nov. 12 at 3:30 PM

#AHA23 AHA Science

VERVE-101 = in vivo base editing designed to turn off the PCSK9 gene durably in liver

professional.heart.org/en/meetings/sc…

Can Lean Mass Help Prevent Alzheimer's Disease? This Mendelian randomisation study explores the link between genetically proxied lean mass and the risk of #AlzheimersDisease . ▶️ Read the full study: bit.ly/3Pj2cCH

Iyas إياس, Dipender Gill

#MedTwitter #MedResearch

Another new pre-print: 'Trans-biobank Mendelian randomization analyses identify opposing pathways in plasma low-density lipoprotein-cholesterol lowering and gallstone disease' medrxiv.org/content/10.110… also led by Guoyi Yang. Brief summary follows:

Can Lean Mass Help Prevent Alzheimer's Disease? This Mendelian randomisation study explores the link between genetically proxied lean mass and the risk of #AlzheimersDisease . ▶️ Read the full study: bit.ly/3Pj2cCH

Iyas إياس, Dipender Gill

#MedTwitter #MedResearch

Proud to say our Mendelian randomization book is now available in Chinese: pmphmall.com/gdsdetail/6477…. This translation is the result of months of co-operation with a network of researchers and academics in China. We hope this enables a wider audience to benefit from its contents.

我很荣幸地宣布，我们的《孟德尔随机化：基于遗传变异的因果推断方法》一书现已具备中文版：pmphmall.com/gdsdetail/6477…。该译本是我们与一群来自中国的研究人员和学者合作多月的成果，我们希望这一译本能让更多的研究人员从中受益。

Out now in AJC ⬇️

Raising important questions about possible ancestry-specific CV disease aetiologies in East Asian and European populations.

Many thanks to the amazing international collaboration
Ravinay Bhindi Usaid Allahwala Dipender Gill Benji Woolf @ DanielHan

authors.elsevier.com/sd/article/S00…