💥Our new paper just out Science Magazine!

Antiviral activity of a human protein of retroviral origin

A study led fearlessly by John Frank

We propose that the human genome encodes a deep pool of antiviral proteins derived from retroviruses!

science.org/doi/10.1126/sc…

Great opportunities Broad Institute for anyone looking for postdoc positions in the areas of machine learning, structural biology, and statistical genetics !!

Congrats Sofia Battaglia, Kevin Dong, Jingyi Wu and co. Long-range phasing of allele specific enhancers!
nature.com/articles/s4158…

Dubrot et al use genome-scale in vivo CRISPR screens to look at #immune_evasion mechanisms across #cancer models, showing that IFN-mediated upregulation of classical and non-classical MHC class I inhibitory checkpoints facilitate immune escape. rdcu.be/cWc9T

Genetic variation associated with condensate dysregulation in disease cell.com/developmental-… Congratulations Salman Banani! 🎊🎉🪅

1/11 Incredibly excited about our story PNASNews just out on an H3K9 #epigenetic driver of enzalutamide resistance, viral mimicry and a blazing interferon (IFN) response in #prostatecancer led by superstars Mehdi Baratchian & Ritika Tiwari doi.org/10.1073/pnas.2…

Wow - it’s out! 🤩Happy to share #EngineeredMelanocytes , new cell models to link #genotype2phenotype in #melanoma devel / progression, out today in Science Magazine. Joint work w/ Eran Hodis John Kwon Levi A. Garraway #AvivRegev (& other🌟collabs ⏬) 1/ science.org/doi/10.1126/sc…

Excited to share our paper “Somatic genomic changes in single Alzheimer’s disease neurons”, published today in @nature!
nature.com/articles/s4158…
[1/19]

Super excited to announce that we’ve just submitted the latest Liau Lab ~manuscript~! Tldr: we used base editors + a methylation reporter to do a mutational scan of DNMT3A, a key cancer gene. Highlights below, but check out our preprint at biorxiv!

biorxiv.org/content/10.110…

Please see our new manuscript in Blood Cancer Discovery describing mechanisms which provide DNMT3A-mutant HSCs a competitive advantage in inflammatory conditions. See virtual poster LB555 from Christine R Zhang #AACR2022 for additional details!

aacrjournals.org/bloodcancerdis…

Please join us on Monday April 4, 8:30am ET Experimental Biology
American Society for Investigative Pathology #EB2022 at Pennsylvania Convention Center, Room 115-B for an exciting symposium on #Epigenetics of #CancerImmunology . asip2022.asip.org/program/asip-2…

Very happy to finally share our work unravelling a physical and functional connection between RNA decay machinery and the HUSH complex to restrict transposable element RNA expression 🙌

Now online in Cancer Discovery: Epigenetic activation of plasmacytoid #dendriticcells drives IFNAR-dependent therapeutic #differentiation of acute myeloid #leukemia Izabela Todorovski pilar dominguez Ricky Johnstone The Johnstone Lab Peter Mac Cancer Centre Peter Mac Research #leusm aacrjournals.org/cancerdiscover…

Our latest preprint is out, with Christopher Douse! Our structure of a KRAB domain bound to KAP1/TRIM28. Gene repression by KAP1 is vital to human development and underpins CRISPRi. We identify residues at KRAB-KAP1 interface required for repression. doi.org/10.1101/2022.0…

The Hematology Division Brigham and Women's Hospital Harvard Medical School is recruiting for clinical faculty as well as basic/translational science faculty positions. See attached description for details.

Saturation variant interpretation using CRISPR prime editing: nature.com/articles/s4158…

Happy #WomenInScience Day from the Bernstein Lab
Brad Bernstein at Dana-Farber News Broad Institute Harvard Medical School !! So inspired to work with this amazing group of scientists #11F2022 #WomenInScience #WomenInSTEM

This is the first chapter of a story about courageous patients and their families, of multidisciplinary teamwork, and hard-fought steps forward to effective therapy for #DIPG #DMG , a universally lethal cancer of the brain and spinal cord.🧵(1/) nature.com/articles/s4158…

Our preprint led by Waihay Wong Connor Emdin & with B. Ebert showing that clonal hematopoiesis is an important (~2-fold risk!) risk factor for chronic liver disease, using complementary data types & experiments in humans & mice. medrxiv.org/content/10.110… medRxiv

That feeling when your 7yo kiddo secretly uses up your last remaining rapid test but you can’t be that mad because the + control looks so good