And the 2nd SigDD conference is over. 2 day full of great talks and scientific discussion. Special thanks for the brilliant invited talks fromCecilia cellfatelab and Jesse jesse veenvliet, and all the participants for creating so stimulating and friendly atmosphere!

jesse veenvliet ISSCR Here is the treatment in the New York Times from 2021. They went with 'mechanical womb.'

I don't think it will be shown that my language is particularly sensational.

jesse veenvliet ISSCR the paper in question uses the term 'ex utero experimental settings' for the roller bottles. I think 'artificial womb' is a correct translation in layman language.

There we go again. Sensationalist journalism with yellow press headlines. Ignoring the call from ISSCR to stop using the term 'synthetic embryo'. For the embryo model field to live up to expectations we need facts, not fiction. Antonio Regalado, you can do much better than this.

Just see this statement in a nature paper: 'Cells were not tested for Mycoplasma nor authenticated as they were purchased less than one year before use'

PSA: I don't care when you purchased... test your cells!

Alejo Rodriguez-Fraticelli, PhD did you see this? biorxiv.org/node/3813628.f…

jesse veenvliet nature Incredibile eh? And guess what might happen to DNA methylation in mycoplasma positive cells 😂😂😂?!

Alfonso Martinez Arias jesse veenvliet It is a legitimate exercise to weigh the conjunction of lab-based human embyro models for science, on the one hand, and attempts to make animals, on the other. There's a very good paper by Alfonso Martinez Arias on this topic: pubmed.ncbi.nlm.nih.gov/37595564/

Antonio Regalado jesse veenvliet ISSCR Yes

jesse veenvliet Cell Systems Elena Camacho Centro Andaluz de Biología del Desarrollo Thanks Jesse!

Warmflash lab Cell Systems Elena Camacho Centro Andaluz de Biología del Desarrollo Congrats Aryeh & team, beautiful & careful work as always!

jesse veenvliet nature So much for #GoodScientificPractise

Alfonso Martinez Arias jesse veenvliet ISSCR fair

Antonio Regalado Could you tell me where can I find a reference for this statement 'several labs are creating super-realistic synthetic human embryos as well'. This is one of the reasons why jesse veenvliet suggests sensacionalism

Pavel Tomancak Oh shit! Good to hear you’re ok

Antonio Regalado jesse veenvliet ISSCR Well, just to clarify. The idea of implanting blastoids is out there and has been tried, but I don't think that it will work through 'empirical' approaches like those described here.

Alfonso Martinez Arias jesse veenvliet ISSCR non story because has 0% chance?

jesse veenvliet ISSCR ISSCR statement said the human models aren't synthetic, are not embryos, and can never come to term. This is *exactly* why it was interesting to cover a project to create a birth in a barnyard from a blastoid.

Antonio Regalado jesse veenvliet They have a different approach, they're not interested in the final product, as those 'cow-boys' but in understanding what's a blastoid & how it relates to a blastocyst. For them, they are the question rather than an ill characterized object to obtain a newborn. They do Science