Our latest article on Neoadjuvant Chemotherapy and Immunotherapy for Estrogen Receptor–Positive Human Epidermal Growth Factor 2–Negative Breast Cancer, just published ascopubs.org/doi/10.1200/JC…
Erin Cobain Laura Huppert, MD Peter Beitsch Hope Rugo Dr. Laura Esserman Laura VAN T VEER YaleBreastCancer

So incredibly well-deserved Hope Rugo!!! Your dedication to patients is unparalleled & your contributions to practice-changing clinical research are truly exceptional. And on a personal note, thank you for being the best mentor EVER! You are amazing! UCSF Helen Diller Family Comprehensive Cancer Ctr

Fantastic panel diving deep into the data for SG and Dato-DXd in breast cancer, including a flurry of trials bringing these agents into the frontine metastatic and neoadjuvant space.

Will traditional chemo become a thing of the past?

#DAVAVictoriaADCs

Amazing & powerful talks by brilliant women on this #InternationalWomenDay at #MBCC2024 ⁦⁦Hope Rugo⁩ ⁦Jennifer Litton⁩ ⁦Laura Huppert, MD⁩ @DrHeatherMcArthur

Laura Huppert, MD from UCSF Helen Diller Family Comprehensive Cancer Ctr summarizes systemic therapy for early-stage TNBC with a roadmap of current treatment algorithm and discussion of future directions - opportunities to deescalate/escalate therapy and trials for neoadj and/or adj ADCs under investigation! #MBCC24

Met the wonderful Paolo Tarantino at Miami Breast two years ago… so fun to be back at #MBCC24 together again and continuing our selfie collection! ☀️

Tune in tomorrow for a day of live #MBCC24 coverage, beginning with timely updates from Laura Huppert, MD of UCSF Helen Diller Family Comprehensive Cancer Ctr, who is taking over the OncLive Twitter account to spotlight key updates in the breast cancer space! PER #bcsm #oncology

Excited to speak at this Society for Immunotherapy of Cancer virtual update on advances in immunotherapy for breast cancer. Register now with the link below!

We are 10 days away from Best of SABCS-West with Hope Rugo! Will you be joining us at the Claremont Hotel Berkeley? A special discounted registration rate of $35 is offered to ANCO members.
Register now: bit.ly/3HnBUdz

#ANCO #BestofSABCSWest2024

Our retrospective multi-center registry of ADC-after-ADC in HER2-low MBC. Most pts have longer PFS on ADC1 vs 2, but not always (so worth trying!) Tx for highlighting VuMedi & for the awesome collaboration Hope Rugo Reshma Mahtani D Idossa, MD Ruta Rao Sarah Premji & others!

Thanks for the leadership Hope Rugo and to all for being such a great team! Fortunate to be part of this fabulous group caring for the best patients! 💕 UCSF Helen Diller Family Comprehensive Cancer Ctr

Beautiful presentation by ⭐️ UCSF Helen Diller Family Comprehensive Cancer Ctr fellow Saya Jacob about incidence of delayed IRAEs. Retrospective analysis of 300+ pt- 25% rate delayed toxicity (>90d post-ICI start) & 7.5% post-tx, mostly endocrine. Prior early IRAE= ⬆️ late IRAEs. Need to keep monitoring post ICI!

Incidence of brain metastases in 17,000 pts with MBC per subtype.

1) Incidence increases per line, except HR-, HER2+ which is early event
2) HER2Low, no impact on BM incidence.

Some fantastic points in the 1st brain mets discussion this am.

🔺LMD is a high unmet need

🔺we are underutilizing real world data for learning

🔺CSF biomarkers may be particularly important as we see more patients with brain only disease

#SABCS23 SABCS #bcsm

The following @GRASPTweets scientists have more to share with us today at #SABCS23 :. Laura Huppert, MD @kalinskykevin Matteo Lambertini, MD PhD @USCFCancer @winshipatemory @unigenova

Laura Huppert, MD presents translational analysis of leptomemingeal disease

57% of LMD had actionable alterations among those HR+

Also observed heterogeneity between CSF, blood, and tumor tissue

#SABCS23 SABCS

What do real-world data say about ADC sequencing and resistance? Dr. Ana Garrido-Castro Dana-Farber’s Breast Oncology Center beautifully summarizes the existing data and stresses the importance of prospective trials and translational science to move the field further forward. #SABCS23