Today was a momentous and sentimental day as the last of my MD PhD cohort defended their PhD! I’m so impressed by all of my classmates’ research and can’t believe how fast six years at SinaiMSTP have flown by!

12 degrees down, 12 more to go..!!! 🎓

Been a blast co-presiding with Joy Jiang & Lauren Stalbow these past two years and working with so many of these fantastic ladies!

So glad this group and space exists for us to connect & support one another through various stages of the MSTP!

This past school year flew by! Thank you to our leadership team for organizing creative events to bring women in our program together! ✨

Michelle Alyssa Tran, PhD Joy Jiang Carina Seah, PhD Cristy Bañuelos Lauren Stalbow Sarah (missing Nicole Hirsh)

Our partnership with Park East HS is now in it's third year, with students visiting labs for the day and learning about our summer research internship program from Ezekiel Olumuyide 🇳🇬🇺🇸 and other immunologists in our graduate and MD-PhD programs.

Congratulations to everyone graduating from
Icahn School of Medicine at Mount Sinai today!

Special shout-out to long-time WiMSTP members: Amara Plaza-Jennings Amara Plaza-Jennings, Camille Van Neste Camille Van Neste, Christie Nguyen, and Louise Malle louisemalle who are graduating with MD/PhDs🎓!!!

Happy APAHM! Excited for the third year of our Soar Over Hate scholarship for college-bound AAPI-identifying students with financial need in NYC! This year we are giving out five $2,500 awards. Learn more below and spread the word!

We are excited to launch our third annual college scholarship for AAPI-identifying high school seniors residing in NYC with financial need! This year we are giving out five $2,500 awards.

Learn more and apply to our Bright Futures Scholarship here: soaroverhate.org/2024scholarship

So happy to see our work published in Cell Reports Medicine! Please check out our paper characterising C100, a fully deacetylated chitin derived polymer, as a potent intratumoral adjuvant for use in in situ cancer vaccination! Joanna Turley Ed Lavelle. cell.com/cell-reports-m… (1/3)

Who will take the sell side of a blobspace derivatives market, and how can we limit their risk?

In this post, I solve for payoff bounds and demonstrate how we can make conditions more favorable for sellers:

mirror.xyz/tamaratran.eth…

Bladder cancer TME-specific TGF-β & hypoxia directly suppress NK cell function via O2-dependent reduction in SLAMF6 signaling Adam Farkas Bhardwaj Lab Michelle Alyssa Tran, PhD Michelle Alyssa Tran, PhD Dr. John Sfakianos Horowitz Lab @Icahn School of Medicine Mount Sinai
biorxiv.org/content/10.110…

Congrats to Adam Farkas for leading this study and elegantly unraveling the role of tissue-specific factors such as hypoxia in suppression of NK cell function in cancer!

biorxiv.org/content/10.110…

Happy International Day of Immunology!

Today we celebrate the incredible advancements in immunology that help protect us from disease and pave the way for healthier futures.

What are you doing to celebrate? Post and tag us for a chance to be featured!

My sister is building a fintech company! Learn more ⬇️!

6/ Thanks to barnabe.eth, Lane 'one meme behind' Rettig, James Prestwich, Life is short, so am I, sydney and neel for the collaboration & edits.

If you're interested in working on these problems, please reach out. I would love to collaborate and connect with other engineers working in the space.

5/ So far, the biggest challenges to me are: (1) the burned base fee making the derivative unsuitable for the natural seller (validators), (2) enabling physical delivery, and (3) protecting against manipulation.

Some more reading on this here: mirror.xyz/0x03c29504CEcC…

4/ Typically, gas markets suffer from lack of a natural seller. In this case, speculators in the community have long argued that the price for blobs should go down over time as bandwidth scales.

I expect that the market will be primarily speculators collecting premiums to start

3/ Blobspace derivatives aim to hedge against these volatility challenges.

Similarly to trading of commodities futures, establishing derivatives markets for blob gas fees creates strategic trading opportunities for rollups (who pay premiums to de-risk their operational costs)

2/ The Dencun upgrade enabled record-high usage and 10x lower fees for L2s with blobs.

However, 10,000%+ gas spikes via Inscriptions soon highlighted their price volatility during high network demand. Future congestion events threaten more unpredictable costs for rollups.

1/ Blobs unlock unprecedented scaling for L2s, but have huge gas spikes and price volatility. They lack financialization like hedging and fractionalization.

I've just quit my job at Apple to build blobspace derivatives & contribute to the ETH ecosystem:

mirror.xyz/0x1Ca8D5E43A19…