Exploring the #genomic architecture of circulating #cytokines in the largest to-date dataset of 75,000 individuals, we find

👉169 loci associated with cytokine levels
👉 promising drug targets for immune-mediated diseases

Check out for more:
medrxiv.org/content/10.110…

Final FY24 budget for US research is a disaster.
Budgets of federal agencies are mostly or cut down

NIH $47.08B flat
NSF $9.06B (-5%)
NASA Sci. $7.33B (-6%)
CDC $9.2B flat
DOE Sci. $8.24B (+1.7%)
ARPA-E 0.46B (-2%)
DOD Sci. $2.6B (-9%)
DARPA $4.1B flat
Global Health $10B (-5%)

📢Three major components of cortical gene expression, differentially aligned w brain development + genetics, transcripts & MRI of neurodev disorders | wonderful work Richard Dear Petra Vertes etal+ | tx Gates Cambridge Allen Institute NIHR Cambridge Biomedical Research Centre

nature.com/articles/s4159…

Because they want to remember the time when they were young and unafraid to challenge dogma

Dalal Hamad Undergrads can do creative, exciting research! My two policies are: don’t bug them a lot, and carve out a project for success that is not in the main line of your research program. Then support and fully include them in your group, and look what happens: stanfordgladstonebeehive.com/ugradpubs

Take a look at how the number of federal regulations and policies governing research at universities has dramatically increased over the years.

This adding an enormous cost of doing research.

(Source COGR)

Delighted to share our work demonstrating that PRS and clinical risk factors should be jointly considered towards personalized medicine. Honored and grateful to be guided by my great mentor Pradeep Natarajan and to work with an awesome team!

Happy to share our paper: Integrative machine learning approaches for predicting disease risk using multi-omics data from the UK Biobank . biorxiv.org/content/10.110…

Now out eLife - the journal! Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis elifesciences.org/reviewed-prepr…

Led by Nguyen Thuy Thuong Thuong OUCRU

This could be huge for UK-EU science

This could be huge for UK-EU science

🎉📣 Latest preprint from the lab: Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction medrxiv.org/content/10.110…

Led by the exceptional Ruidong Xiang (now head of comp bio at AgriBio Agriculture Victoria)!

Amen. When I interviewed at Bell Labs at the end of graduate school, I was asked to prepare a 45 min talk that took me 90 min to deliver -- thanks to all the interrupting questions and debate that ensued. It was fantastic! It meant that they cared, and they pushed me in

We're inviting people living in the East of England to tell us what matters to them when #NHS data is used for health research.

Join us on Monday 29th April:
10:30 - 12:00 pm - Webinar introduction
1:00 - 2:00 pm - Choice of 3 workshops

Register at eventbrite.co.uk/e/have-your-sa…

Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158…

I break the key findings down panel by panel in this thread: x.com/cureffi/status…

Investigational medicines with human genetic support for their mechanisms are 2.6-fold more likely to successfully make it to regulatory approval vs those without nature.com/articles/s4158… nature

Excellent news and a significant milestone for the project 🎉

#HLRI looking lovely in the (sort-of) sunshine today!