Neuroinflammation

Neuroinflammation is defined as an inflammatory response within the brain or spinal cord. This inflammation is mediated by the production of cytokines, chemokines, reactive oxygen species, and secondary messengers.

OMG cytokines on the BBC! My jaw is still on the floor. #LongCovid 1/2

NEW STUDY - mRNA COVID-19 vaccine lipid nanoparticles (LNPs) trigger the production of pro-inflammatory cytokines in 75% human serum. Now it can be inferred that some vaccine adverse events may stem from the LNPs in addition to the produced Spike protein (Parry et al).
#MFScholar …

Anti-Diabetic
Improves insulin sensitivity[1]
Anti-Fungal (antifungal)
Antiinflammatory
Reduces inflammation as judged by plasma cytokines.[1:1]
Prevents inflammation from high fat diet-induced obesity.

We have to pay attention to the visceral fat. In skinny-fat people, this is not very obvious from the outside

High visceral fat releases cytokines - immune system gets activated. Thus fat tissue is an endocrine organ, communicating with brain, liver, pancreas, muscles

With high…

C-Reactive Protein (CRP) is widely recognized as a sensitive and nonspecific marker for inflammation. Elevated CRP levels are observed in response to acute inflammation, infection, and tissue damage due to its production by the liver, stimulated by cytokines such as…

$CRVS #Soquelitinib significant advantages over current #atopicdermatitis #asthma therapies:
SQL oral vs mAbs subcutaneous/IV
8-10 cytokines blocked at once vs only 1-2 by others

Potential is HUGE
$RGN #Dupixent $8.9B
$NVS #Cosentyx $4.8B
$ABBV #Skyrizi $5.2B
$JNJ #Stelara $9.7B

#ILC2 play a central role in atopic dermatitis (AD), releasing inflammatory cytokines.

Cytokine profile of healthy v eczema (AD)

$SNY $REGN #Dupilumab blocks only IL-4/13 signals
$CRVS #soquelitinib stops ILC2, #Th2 , #Th17 upstream and should bring more ILs to normal levels!

mdpi.com/2072-6643/16/6…

VitD counteracts inflammation with multilevel targeting effects, i.e., inhibiting the expression & signaling of TLR2, 4, and 9, reducing the production of cytokines such as TNF-a, IL-6, and Il-23, + repressing the activity of T cells recruiting chemokines

ion of pro-inflammatory cytokines. SF was shown to suppress liver inflammation within 24hrs of treatment. SF was not associated with any cellular toxicity, indicating the protective effect of SF against inflammatory responses.

#cordycepsmilitaris
#CordycepsMilitarisMarket

Regulating Cytokines: Cytokines are signaling molecules that orchestrate immune responses. Cordyceps help balance cytokine production, promoting a well-regulated immune system.
wa.me/p/665451079798…

vitamin e is one of the most important nutrients. it detoxes BPA, lowers prolactin, among other things. but one thing I just found is a bit concerning:

'in healthy control subjects, the effect of α-tocopherol supplementation on the production of inflammatory cytokines appears to…

The immunology of #LongCovid . Increases in pro-inflammatory cytokines, especially IL-6. Perturbations in innate immune cells. NK cells need more research. Discoordination between B and T cells response.

Open access. Exercise and Manual Therapy influence on pro-inflammatory cytokines. ChadCookPT Damian Keter PT frontiersin.org/articles/10.33…

The Benefits of a Good Night's Sleep: Part 3

Regulation of Inflammatory Cytokines:

Sleep plays a crucial role in regulating the production of cytokines, which are proteins secreted by immune cells that influence the inflammatory response.

During sleep, especially slow-wave…

Visceral fat produces inflammatory cytokines associated with:

- Insulin resistance

- Type 2 diabetes

- Hypertension

- Atherosclerosis

- Cardiovascular disease

- Liver disorders

Anti-Diabetic
Improves insulin sensitivity[1]
Anti-Fungal (antifungal)
Antiinflammatory
Reduces inflammation as judged by plasma cytokines.[1:1]
Prevents inflammation from high fat diet-induced obesity.

$CRVS each cytokine blocked worth ~$4.8B-$9.7B in #autoimmune diseases #IBD #ulcerativecolitis #atopicdermatitis #asthma #psoriasis
Current drugs mAbs are IV/subcutaneous, only stop 1-2 cytokines.
$CRVS #soqeulitinib is oral and stops 8-10!
What would a drug like that be worth?

Kick-start sharing 3 of our lab research in #Immunology2024
@ Block Symposia Sections- 'Microbial and Parasitic Infections' & 'Cytokines and Chemokines in Pathophysiology'
@ Poster Section - 'Inflammation and Signaling in Hematopoiesis and Myelopoiesis'
AAI