5 days until the deadlines for abstracts & scholarships for Single-Cell Proteomics Conference.

single-cell.net/proteomics/scp…

I still remember vividly the talks by Steve McCarroll and Ralph Weissleder.

Ralph presented a sweeping panorama of problems needing single-cell proteomics.

youtu.be/a_xt37XoLDg?si…

We first met in June 2018.
Since then, every meeting has reflected the annual progress of our community.

Based on the abstracts, 2024 will not disappoint.

I can barely wait for my teams to share results from Slavov Laboratory and Parallel Squared Technology Institute (PTI).

single-cell.net

Nanopore direct RNA seq & siRNA knockdowns help identify pseudouridine sites and their synthase enzymes.

Well done Sara Rouhanifard and team!

We are hiring !
The opportunities are for colleagues who want to pursue big bold ideas in a well-resourced non-profit environment.

We support open science & career growth.

Requirements: Enjoying challenges & collaborations.

parallelsq.org/careers

Please RT.

We are yet to investigate proteomes with unbiased discovery-driven methods.

Yet, the prospects are good.
We may soon enter an age of discovery when proteomes are routinely explored at scale and their secrets revealed.

nikolai.slavovlab.net/Proteome-secre…

Let's elevate our scientific discourse:

◼️ Replace adjectives with factual statements
◼️ Offer constructive criticism
◼️ Place results in context where they can be better appreciated
◼️ Make research results accessible to broader audiences

blog.slavovlab.net/2020/07/15/pro…

As we celebrated our 1st anniversary, we reflected on a year of building up, launching projects and establishing collaborations.

parallelsq.org/blog/celebrati…

I am frequently asked questions that are answered in this Nature Methods article.

So, I will re-share it.

nature.com/articles/s4159…

Shout out to Prof. Nikolai Slavov for a fantastic talk on high throughput #singlecell #proteomics by mass spec & 🙌🏻 for all their efforts on making this technique & downstream analysis accessible to the scientific community NextGen Omics

more info at slavovlab.net

Good point.
How should we name new phenomena that we do not yet understand ?

I favor phenomenological terminology describing the measurements; that's what we have used.

E.g., introducing high oxygen consumption (HOC) helped.

molbiolcell.org/doi/full/10.10…
pnas.org/doi/full/10.10…
1/2

Proteins are dynamic.
These dynamics animate life.

Today we will celebrate the 1st birthday of PTI !

parallelsq.org

Why do a PhD ?

blog.slavovlab.net/2023/03/11/why…

Even when protein levels do not change in time, their covariation within timepoints changes substantially.

biorxiv.org/content/10.110…

I just wrote a blog post about a conviction of mine.

Choosing between great research or great mentorship is a false choice:
◼️ One may succeed at both or is likely to succeed at neither.

Research, mentoring, & teaching are highly synergistic.

nikolai.slavovlab.net/Research,-ment…

Jason Derks (Jason Derks) is heading to US HUPO to present results from our group.

ushupoconference.org/speakers

Registration is open for the Barnett Institute 50th Anniversary and Karger Medal Celebration

cos.northeastern.edu/barnett/about/…

Much progress comes from young scientists & engineers who underestimate the difficulty of their dreams.

So, they embark upon a journey towards mountains shrouded in fog and mystery ...

... and chart an arduous & rewarding trail of discoveries.

Be bold
Dream big
Celebrate life

The sheer scale of the proteome is forbidding.

New ideas and technologies are scaling up to the enormity of the proteome.

The biology vistas will be spectacular.

blog.slavovlab.net/2023/11/29/pro…