ADAD and mAbs in DIAN. Bottom line - neither abeta mAb cleared amyloid like leca or dona, so the hypothesis that what matters is prompt and complete amyloid clearance was not tested. No clinical effects modest biomarker changes, shoulder shrug. alzforum.org/news/research-…

Hmmm nice to see clinical academia promoted here but article fails to acknowledge the big issues we face atm - partly as a result of RCP taking its eye of the ball imo.

In my boot for another 3 weeks but at least my consultant is happy for me to partly weight bear. So sick of this now must admit terrible patient. I need some crags to climb and dog walks.

Agree this myth needs to be tackled. Often enough, the many people who claim the field is too amyloid centric are already pursuing the alternatives, with varying success.

£16bn to be spent by Wellcome between 2022 & 2032

Mental health one of three urgent health challenge foci (alongside infectious disease and climate & health)

“How can we find new solutions — pharmaceutical but also behavioural and digital — in the mental health space? “

When prion disease Isn’t suspected: prion disease as the cause of terminal decline in chronic mixed dementia. I have never diagnosed this situation in life, as the authors note it would be unusual to investigate so extensively for a change in course. tandfonline.com/doi/full/10.10…

I'm working with CJD Support Network UK to run a virtual craft and coffee morning for people who have been affected by CJD on 24 May. Find out more:
tinyurl.com/CJD-craft

Lewy body pathology is found in ~50% of both sporadic and familial Alzheimer's disease. Levin et al. showed that:

1. 0/26 of asymptomatic and 3/27 (11%) of symptomatic AD mutation carriers tested positive on an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid.…

V337M and R406W are the first known mutations in the microtubule-associated protein tau gene that give rise to filaments with the Alzheimer tau fold.
biorxiv.org/content/10.110…

Opening for a consultant in diagnostic #neuropath in Sheffield Hospitals. Adult & paeds, surgical & post mortem. Strong links with Neuroscience Institute (neurodegeneration and neoplasia).

Close to Peak District National Park (walking, climbing, cycling). This is Stanage Edge, <6miles from the department!

This is the moment that the Millennium Falcon crash lands on the Ivinghoe Beacon in The Rise of Skywalker. The ruins of the Death Star were superimposed over my house. I’m not kidding.

This is a useful knot but personally would like to see a bit more spare rope at the end, maybe 5 inches or more

Will Self on the MyCare-type Patient Apps and related issues. I didn’t know of his blood cancer diagnosis but wish him well and hope for a full recovery - it hasn’t suppressed his sardonic style that’s for sure. bbc.co.uk/sounds/play/m0…

Super work Ali promoting both non-motor symptoms in ALS and the development of synthetic controls, amongst other things during the pandemic. Well done you can be proud of this work!

Congratulations to Ali Shojaie on passing his PhD viva today 🥳🍾 and thank you to Prof Simon Mead Simon Mead and Dr Tom Lambert for examining and Dr Ahmad Al-Khleifat and K Ray Chaudhuri for co-supervising.
#ALS #MND #nonmotorsymptoms

Jenny Vaughan obituary | Doctors | The Guardian what a wonderful and passionate contribution to the good and just working lives of doctors theguardian.com/society/2024/a…

for clinical academics
-flexibility in training schemes to allow CCT ~age 37
-NHS & Unis work to cut duplicated stat & mand
-sort out RnD bureaucracy once & for all
-stop academic pay penalties
-diminish intermediate stage bottlenecks
-allow academic aptitude in recruitment