Is this possible? AlphaFold3 predicts an ordered BRCA2 protein in the presence of Rad51 filament. All 3391 amino acids folded into ordered structure. #BRCA2 #HR #breastcancer

うちのイッヌに長生きして欲しいから、今回買ったNMNパウダー私と共同使用にしようかな👀

結構老犬や老猫にあげてる人多いよね🐶🐱

🚨STUDY: JUNK FOOD WILL ACTUALLY KILL YOU

A new study shows that methylglyoxal, produced from breaking down junk food in your gut, shuts off the BRCA2 gene, raising cancer risks by inhibiting tumor suppression functions.

Regular consumption is linked to significant disruptions

Previously, sugar has been linked to cancer for being the fuel of choice of existing cancer cells.

Now, new research shows how sugar can trigger the start of cancer.

When sugar is metabolized, it forms methylgloxal (MGO), which then turns off BRCA2, a tumor suppressing gene.

乳がんの手術受けてから3ヶ月と20日(110日)経ったんだけど、

今までほぼ感覚が無かった摘出部がチクチクと痛む…🥲

ごっそり組織がないから一生無感覚なのかと思ったんだけど、神経が戻ってきてるみたい⚡️

I AM 10 YEARS CANCER FREE!! 🎉

TODAY #OnThisDay 10 yrs ago I had my last radiotherapy dose following a yr of #cancer treatment
Fantastic #NHS care Royal Free London forever grateful 🙏🏼

#breastcancer #brca2 #NHS 75
#NHS Birthday #NHS 75Women

How it started How it's going

Singapur Üniversitesi 'ndeki araştırmacılar, aşırı işlenmiş gıdaların nasıl kanser ile bağlantılı olduğuna dair bir başka açıklama daha getirmiş.

Metilglioksal, vücut yağları ve şekerleri parçaladığında açığa çıkan bir bileşik.
Araştırmacılar, metilglioksalın BRCA2 adı verilen

As someone who had this surgery prophylacticly since I am BRCA2 + I would not wish this surgery or an oopherectomy on anyone. Your life will never be the same and shock menopause is a living hell. So sad young people are convinced to do these surgeries. Can’t wait for these

สปสช. ชวนผู้ป่วยมะเร็งเต้านมทุกคนปกป้อง “คนที่เรารัก” และ “คนในครอบครัว” ห่างไกลจากโรคมะเร็งเต้านมทำแบบประเมินคัดกรองสุขภาพว่าท่านเข้าเกณฑ์เป็น“กลุ่มเสี่ยงสูงที่จะมียีนมะเร็งกลายพันธุ์หรือไม่” และเข้ารับบริการตรวจคัดกรองการกลายพันธุ์ของยีนมะเร็งเต้านม (BRCA1/BRCA2)

📌

IA PARA O BEM!!!

Para quem não sabe uma das maiores aplicações de IA atualmente é na resolução das complexas estruturas de proteínas, nesse caso a AlphaFold3 prevê uma proteína BRCA2 ordenada na presença do filamento Rad51. Todos os 3391 aminoácidos dobraram-se em uma estrutura

beforeは正面からで、afterは斜め上からの写真で明らかに目の高さが違うから、

単純に顎の長さだけ差尺出してても意味ないし明らかに盛ってるけど…

この変化量は正に転生だね〜👀✨️

でもちゃんと写真は撮って欲しい📸

#Genommedizin
Was haben die Gene BRCA1 und BRCA2 mit Brustkrebs zu tun?
Die Universitätsklinikum Heidelberg, Partner von genomDE, hat ein Video veröffentlicht, das die Zusammenhänge und den Ablauf einer genetischen Sprechstunde für Betroffene erklärt. Uniklinik Köln Haus der Krebs-Selbsthilfe Bundesverband e.V.

👉shorturl.at/gnMS1

数が少ないからなんとも言えないところはあるかもですが、gBRCA変異ありでもアジュバントのアベマシクリブは期待できそう。
RB1はやはり効果に影響しそう。somatic BRCA2も影響しそうだけど、これってやっぱりRB1とオーバーラップしてるんだろうか。
#ESMObreast24

At #ESMOBreast24 Christine Desmedt presents an analysis of germline BRCA1/2 mut and uncommon somatic alterations from pts enrolled in monarchE
➡️Consistent abemaciclib benefit for all muts except somatic RB1 and BRCA2
Small sample size requires cautious interpretation‼️
OncoAlert

เผย ผลแบบคัดกรองสุขภาพ “ประเมินความเสี่ยงรับสิทธิตรวจยีนมะเร็งเต้านม” พบผู้ป่วยมะเร็งเต้านมมีความเสี่ยงเข้ารับบริการคัดกรองยีน BRCA1/BRCA2 สูงถึงร้อยละ 10

nhso.go.th/news/4404

Ashok Venkitaraman & colleagues address a fundamental question that has plagued the BRCA field for years - why do individuals with monoallelic germline mutations of BRCA2 still get cancers like #PancreaticCancer , sans a classic “second hit”. Fantastic study tying aberrant

Las células inmunes 'agotadas' en mujeres sanas podrían ser un nuevo objetivo en la prevención del cáncer de mama.
Todos tenemos los genes BRCA1 y BRCA2, pero sus mutaciones -que pueden heredarse-, aumentan el riesgo de cáncer de mama y de ovario. Investigadores encontraron
1/

A byproduct of glucose metabolism (MGO) temporarily de-activates the tumor suppressor gene BRCA2, leading to more breast cancer. Oh, and you know what IMPROVES insulin resistance.... Estrogen.

cell.com/cell/fulltext/…

BRCA2+のため、卵巣癌のサーベイランスを受けてきました❗
癌所見なし✨️
ただ、子宮腺筋症の診断を受けました😅
癌に比べたらなんてことなく、あぁだから経血が多かったのかー、なるほどーって感じ😅
今受けている内分泌治療がこの子宮腺筋症の治療にもなっているらしくそのまま様子見です👍

Exciting new data from #EAU24 on treatment for mCRPC patients:

The combination of a PARP inhibitor + an androgen receptor signaling inhibitor is showing efficacy as an initial treatment approach, especially for those with BRCA1 or BRCA2 mutations.

tinyurl.com/5yr76d68