Researchers in the Worcester Biomedical Research Group UoW BioMed Research have identified a new biomarker which may be useful for predicting heart attacks. 🩸🫀🧑🔬👏
#UoWBioSci #BiomedicalScience #Medicine #Cardiology
Read more about it here 👉
worcesternews.co.uk/news/24276462.…
Thank you to PennLive.com for amplifying this message--on why access to biomarker testing is critical for patients across the disease spectrum.
🔴 Congestion in heart failure: a circulating biomarker-based perspective #openaccess #Review
onlinelibrary.wiley.com/doi/10.1002/ej…
#congestivenephropathy #CardioEd #Cardiology #MedEd #ENARM #cardiotwiteros #meded #cardiology #CardioTwitter #CardioEd #medtwitter
4. Yes we can! Viral antisense RNA is a 'decent' diagnostic biomarker for #LongCovid but together with immune marker FYN it's even better:
4.1. multivariate logistic regression (corrected for age and sex, table below)
4.2. identify Long COVID with >90% sensitivity and specificity
It was a fantastic presentation by Dr. Rosa Neto, Pedro - from TNL/McGill Research Centre for Studies in Aging 🇨🇦 about the biomarker-based staging of Alzheimer's disease.
#AAICNeuro #AAICNeuro POA Alzheimer's Association
The #SARSCoV2 viral RNA signature in people with #LongCovid markedly differs vs controls
thelancet.com/journals/lanmi… The Lancet Microbe
Also linked to symptoms.
Not only indicative of persistence, but also potential as a biomarker Johan Van Weyenbergh marc jamoulle KU Leuven
Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical Robustness. Click the link below to read this free, open access article. #special_issue #Intelligent_Drug_Delivery_Systems doi.org/10.34133/2022/…
This study shows that dd-cfDNA, a noninvasive biomarker for rejection risk, can be used to help inform physician decisions regarding IST reduction in KTx patients, along with patient evaluation and other clinical factors. #OpenAccess #TransplantTwitter tinyurl.com/45s8sr9z
Have a read on my new piece on #biomarker discovery in #oncology for #pharma and #biotech in
rdworldonline.com/for-drug-disco…
Note the value of Oxford Nanopore flexible platform: short and long reads as well epigenetic information included.
What you are missing matters!
So now some statistics to answer the following:
4. can we use persistent RNA in blood (+/- 2 years after acute COVID in this cohort) as a diagnostic biomarker for #LongCovid ?
5. what predicts high vs. low blood viral load in #LongCovid ?
Let's talk about procalcitonin.
It's a biomarker that, when negative, suggests safe to stop/not give abx.
Meta-analysis below of 26 RCTs: PCT-guided = less abx, less adverse effects, less mortality.
Guess how many RCTs the CAP guidelines cite?
0 🤔
#SHEASpring2024
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zeynep tufekci marc jamoulle Rob Wüst Question 2 is one I always have with students. What reason do we have to remove outliers for a new biomarker in a new disease? Dismiss 3 patients because their results are 'too high to be true' is not good science IMHO. But as expected, removing does not change result (non-param)
🔍Discovering that aggrecan is a key biomarker in ascending aortopathy is a groundbreaking advancement in our understanding of aortic diseases! Excellent work by the team Eric E. Roselli Benjamin Kramer, DO, MS Cleveland Clinic Heart, Vascular & Thoracic AATS #Aortic2024
Extending about 9 weeks the interval dosing of ocrelizumab in #MultipleSclerosis did not result in clinical, radiological, or biomarker evidence of worsening.
Prospective, double-arm, open-label, multi-center study in 🇩🇰 Uni Southern Denmark ▶️ journals.sagepub.com/doi/10.1177/13…
