急性心不全患者におけるダパグリフロジンの有効性と安全性はどのくらい？（Open-RCT; DICTATE-AHF試験; J Am Coll Cardiol. 2024） dlvr.it/T5NsKG

Excited to present the #DICTATE -AHF results European Society of Cardiology #ESCCongress2023 later today. HOTLINE 8 is going to be a great session full of important clinical trial results

DICTATE-AHFの論文が出たようですね☺

jacc.org/doi/abs/10.101…

A Ph3 dapagliflozin trial (DICTATE-AHF) in T2DM patients with acute decompensated heart failure was observed on CT.gov. The study is assessing the decongesting effects of dapagliflozin & protocolized diuretic therapy in ADHF patients: bit.ly/FENIX267729

📌 #DICTATE -AHF : negativo
💊 Dapagliflozina en #IC aguda

🤫No son diuréticos….. (ya lo sabíamos😉)
🤦🏻‍♀️Eligieron como end point: 𝐜𝐚𝐦𝐛𝐢𝐨 𝐚𝐜𝐮𝐦𝐮𝐥𝐚𝐭𝐢𝐯𝐨 𝐝𝐞 𝐩𝐞𝐬𝐨 🗣️ya sabemos es una medida no confiable

👥238 (de 3672 solo el 7% se randomizó) 🤔es IC aguda

#DÍCTATE -AHF: early initiation of dapagliflozin in AHF🏥

👉 Totality of DICTATE-AHF data supports the early initiation of dapagliflozin in AH to safely facilitate decongestion and GDMT optimization European Society of Cardiology #ESCCongress

#HeartFailureDays
#HeartFailureWeek

#SGLT2i in #AcuteHF
#DICTATE_AHF
#Dapa confirmed:
-Effective decongestive effect ✅
-Diuretic & Natriuretic effect ✅
-Significant ⬇️ of mean loop-diuretic dose
-Shorter length of 🏥 ✅
-No AE ✅
🍀 On-top of SGLT2i ⬇️ of ☠️

#Findme
Gregg Fonarow MD

Efficacy and Safety of Dapagliflozin in Acute Heart Failure: Rationale and Design of the DICTATE-AHF trial

Read more - bit.ly/36vD1pE

#metabolicsyndrome #metabolichealthdigest #hypertension #heartfailure #bloodpressure #highbloodpressure #dapagliflozin

📌Efficacy & Safety of #Dapagliflozin in 👥 With Acute #HeartFailure

🔸Early dapagliflozin during AHF hospitalization was safe & fulfills a component of #GDMT optimization

#DICTATEAHF

#ESCCongress Hotline #DICTATEAHF
🎯early initiation of dapagliflozin in AHF🏥 RCT Dapa (w/in 24h) vs UC acute tx-39% 💃🏻
🎯 Dapa provided improved diuresis and ⤵️ diuretics + ⤵️🏥 stay
🎯 Supports start GDMT fast & Dapa early even if they didn’t meet 1o endpoint

ESC2023@Amsterdam、Hotlineの演題が公開されましたね！超大型トライアルはないですが、個人的には、Groningenの仲間のJozineとKevinのPUSH-AHF、AHF急性期(<12h)のDapagliflozinの効果を見たDICTATE-AHF、高齢フレイル患者のDOAC vs. VKAのFRAIL-AFでしょうか。今から楽しみです❗️ #ESCCongress

急性心不全患者におけるダパグリフロジンの有効性と安全性はどのくらい？（Open-RCT; DICTATE-AHF試験; J Am Coll Cardiol. 2024） pharmacyebmrozero.com/2024/04/12/%e6… 猫薬プロジェクト3rd〜ある薬剤師の備忘録〜より

👆👇 #HeartFailureDays
#HeartFailureWeek

#DICTATE_AHF

#SGLT2i in #AcuteHF confirmed multiple clinical benefits without Adverse Events

🍀 On-top of SGLT2i ⬇️ of ☠️

The 1st choice to decongest & ⬆️ survival of our #HF patients

#Findme

bit.ly/4dmoGgc

American College of Cardiology

#ESCCongress 2023
🔥 #DICTATE_AHF #dapa in #AHF
👉 ⬇️ Cumulative dose of loop-diuretics
🔄 No change in weight
✅ Natriuretic Effect
✅ Diuretic Effect 👌
Great news waiting for #DAPA_ACT_HF_TIMI68

Gregg Fonarow MD Javed Butler Shelley Zieroth Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Ritu Thamman MD Giuseppe Biondi-Zoccai

【ESC 2023】DICTATE-AHF試験より、急性心不全患者において、SGLT2阻害薬ダパグリフロジンの早期投与開始は、標準的な管理と比較して利尿効率を改善する傾向が見られ、安全性の問題は認められなかったことが発表されました。
tcross.co.jp/meeting/esc/58…
#ESC2023 #テクロスニュース

【循環器 注目の論文】DICTATE-AHF試験より、急性心不全患者において入院早期のダパグリフロジンの投与は、安全なガイドラインに基づく標準的治療（GDMT）の至適化につながったことが報告された。
tcross.co.jp/news/jacc/6533…

L’introduction précoce de dapagliflozine en hospitalisation, pendant un épisode d’IC aiguë, pourrait améliorer l’efficience de la décongestion cardio-online.fr/Actualites/A-l… #ESCCongress Charles Fauvel

SGLT2 Inhibitors in Acute Heart Failure The Earlier The Better DICTATE AHF - Medscape
alimarketing.pk/2023/10/13/sgl…

#EMPULSE trial: Rationale&Design of #Empaglifozin vs Placebo in 🏥 #AHF
Another barriers that is being overcome by #SGLT2i
#SOLOIST_WHF #DICTATE_AHF #DAPA_ACT_HF_TIMI68
Adriaan Voors Kamala Tamirisa MD Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Mamas A. Mamas Danielle Belardo, MD Dr Anastasia Mihailidou FAHA FCSANZ FESC
onlinelibrary.wiley.com/doi/10.1002/ej…

3️⃣ #DICTATE_AHF 🔥
Early DAPA Initiation in?👥 w T2DM & eGF ≥30 in 🏩 w Acute #heartfailure
❓DAPA on top of IV loop diuretics:
🥇
↔️no sig. change in Diuretic efficiency
🥈
⬆️24-hour natriuresis✅
⬆️24-hour urine output✅
⬇️time to hospital discharge✅
#ESCCongress #Diabetes