TREM2 as a positive regulator of Macrophage #FoamCell mitochondrial function, survival & efferocytosis under hypercholesterolemic stress
Hematopoietic TREM2 KO⏫ #NecroticCore formation in early (8~12 wk), not late (16~20 wk) #Atherosclerosis in Ldlr-/-🐭
w/o altering lesion or…
#Mechanobiology #SmoothMuscleCell
#Piezo1 & Pressure (hypertensive 180/120 mmHg) ▶️cPLA2-mediated #LipidDroplet formation & #FoamCell phenotype in SMC in 2 h🤠
SMC Epigenetics by 8 h Yoda1 (Piezo1 activator): LAD-heterochromatin, H3K9me3 Cut&Tag
Piezo1 enriched at SMC nuclear…
Welcome to read the #highcited paper in Frontiers in Bioscience-Landmark:
Intracellular transports and atherogenesis, by Alexander A. Mirоnоv et al fbscience.com/Landmark/artic…
#Atherosclerosis #LDL #HDL #Transcytosis #EndothelialCell #Chylomicron #Intima #FoamCell #Lysosome
Welcome to read📣Intracellular transports and atherogenesis, by Alexander A. Mirоnоv from The FIRC Institute of Molecular Oncology
imrpress.com/journal/FBL/25…
#atherosclerosis #LDL #foamcell #EndothelialCell #cardiovascular #cellbiology
Modeling Monocyte-to- #FoamCell transition
3D #EndothelialCell (SVEC-10) #SmoothMusclecell (MOVAS) #Monocyte (RAW264.7) collagen co-culture
+Glucose/LPS
SMC⏫
Mɸ Adhesion
Mɸ Transendothelial migration
Mɸ/SMC Foamy transition
Adv Biol 2024 Advanced Sci News
onlinelibrary.wiley.com/doi/10.1002/ad…
#SmoothMuscleCell -Macrophage Interactions Leading to #FoamCell Formation in #Atherosclerosis : Location, Location, Location
'macrophage-secreted LAL may be taken up &⏫cholesterol efflux from nearby SMC foam cells'
Dr Gordon Francis lab Frontiers - Physiology 2022
frontiersin.org/articles/10.33…
#clearcytoplasm
#hyalinizedvessel
#foamcell
#foamycytoplasm
#SMARCE1 twitter.com/neuropathobern…
Ironman foamcell
#ironman4x4 #ironman4x4 indonesia #tas4x4 #ironmanfoamcell #shockfoamcell #shockabsorberfoamcell instagram.com/p/Bu_b3JtAQSC/…
LAMTOR/Ragulator regulates #lipidmetabolism in #macrophages and #foamcell differentiation →febs.onlinelibrary.wiley.com/doi/full/10.10… #metabolism #celldifferentiation #lysosome #endosome #mTOR #iTRAQ #proteomics #transcriptomics #cellsignaling
#YAP ⏫ #Lipogenesis via SGK1-mTORC1-SREBP axis in MCF10A mammary epithelial cell in vitro &🐭hepatocyte in vivo!🤠
Does this YAP-lipogenesis cascade work in other cell types eg. SMC-derived #FoamCell ?
Dr. Andrew Cox & Kristin Brown labs Developmental Cell 2022
sciencedirect.com/science/articl…