An inspiring meeting on #MDSsm with ⁦Sanam Loghavi, MD صنم لغوی 🔬🧬⁩ ⁦@olsneskittang⁩ ⁦Shahram Kordasti⁩ Stay tuned for #immunology news… good things happening here. #london

Bone marrow #inflammation in haematological malignancies
nature.com/articles/s4157…
#MDSsm #MPNsm #leusm #MMsm

Our study on clonal evolution in Fanconi anemia is out in Cell Stem Cell. In the FA background of chromosomal instability & HSC attrition, trisomy 1q/MDM4-driven p53 downregulation yields clonal hematopoiesis, preceding sAML.
authors.elsevier.com/a/1gX1h6tu0Cm4…
#BMFsm #leusm #mdssm #AMLsm 1/2

Cardiac effects of deferasirox in transfusion-dependent patients with myelodysplastic syndromes: the TELESTO study onlinelibrary.wiley.com/doi/10.1111/bj… #mdssm #leusm

Had the opportunity to discuss what we have learned about immune targets in MDS at #MDS2023 #mdssm

Portrait unveiling at the conclusion of the John F DiPersio Immunotherapy Symposium
WashUOncology Siteman Cancer Center WUSM Department of Medicine Washington U. Med Barnes-Jewish Washington U. DBBS WU Division of Physician-Scientists
#bmtsm #celltherapy #cartcells #leusm #lymsm #mmsm #mdssm

Finally out in AmericanJournalofHematology!
In adults with :
1⃣hypereosinophilic syndromes AND
2⃣“myeloid” features (splenomegaly, ⇑ tryptase, other CBC abnormality, corticoR) AND
3⃣lacking tyrosine kinase fusions
👉>50 % have mutations in the JAK-STAT pathway
#MDSsm #MPNsm #leusm #CEREO

Practice-changing results at #EHA2023 Plenary session:
Luspatercept moves into 1st line for transfusion-dependent low-risk MDS!
Superior transfusion independence compared to Epoetin alfa!
Important step for patients!
@ matteodellaporta G Garcia-Manero MDS Foundation
#MDSsm

Who was your childhood/teenage years science hero? Carl Sagan here! (& didn’t choose to work on #MDSsm because he died from it, just a coincidence)…

Our perspectives NIH Fred Hutchinson Cancer Center Stanford Medicine in Blood Journal on
How I reduce and treat posttransplant relapse of #MDSsm ashpublications.org/blood/article-…

Which #MDSsm patients are most likely to have UBA1 mutations associated with #VEXAS syndrome?

Our study now out in Blood Journal: Molecular and clinical presentation of UBA1-mutated MDS by Elli Papaemmanuil, PhD, Elsa Bernard, Maria Creignou, David Beck, MDS IWG-PM & MDS Foundation

The Yale University Yale UniversityCancer Yale UniversityHemOnc Yale UniversityHematology delegation in the #MDSsm #MPNsm conference

So excited to present the five year follow up results of phase 2 single arm clinical trial conducted MD Anderson Cancer Center evaluating Aza + Rux in MDS/MPN overlap syndromes! #ASH23

ORR : 54%, DoR : 35 months
mOS: 31.8 mo

Link : ash.confex.com/ash/2023/webpr…

#leusm
#mdssm
#mpnsm

I ❤️ my patients and their caregivers. They are the most amazing, brave & kind people I know. What a privilege to take care of #leusm & #mdssm patients. ⁦The James⁩

⁦Maria Amaya, MD PhD⁩ takes the podium at the University of Colorado ⁦CU Anschutz Division of Hematology⁩ ASH review to fill us all in on the recent updates in AML and MDS! #AMLsm #MDSsm

Lisa McReynolds from National Cancer Institute discusses the role of genetic testing in #SAA and #MDSsm . AA&MDSIF

Venetoclax plus hypomethylating agents in DDX41-mutated acute myeloid leukaemia and myelodysplastic syndrome: a Mayo Clinic series

onlinelibrary.wiley.com/doi/10.1111/bj…
#leusm #mdssm #DDX41 Mrinal Patnaik Mark Litzow Aref Al-Kali Naseema Gangat

Entertaining collegial debate alert! Maximilian Stahl Dana-Farber News dives into the role for frontline luspatercept use for #MDSsm ! 🚀 Energizing insights, engaging discussion! 👇 ! #MedTwitter MD Education US Focus 5th annual meeting 👏👏🎊🎊It’s all about the Win 😂👏

#MichaelSavona presents a captivating talk on the role of Imetelstat in MDSsm MD Education! US focus Meeting. New promising agent, enlightening talk. #innovative !! 🎊🎊Vanderbilt Hem / Onc Vanderbilt-Ingram Cancer Center 👏👏 New Hope for LR-MDS.

It was a great pleasure to meet Professors J.J. Kiladjian and Lionel Ades and gain invaluable insights from their guidance.
#MPNsm #MDSsm #CMML