Happy to share our preprint:
Stimulation of NCAM1-14.3.3.ζδ-derived Peptide Interaction Fuels Angiogenesis and Osteogenesis in Ageing
biorxiv.org/content/10.110…

Happy to share our work:
Stimulation of NCAM1-14.3.3.ζδ-derived Peptide Interaction Fuels Angiogenesis and Osteogenesis in Ageing
biorxiv.org/content/10.110…

Brilliant work presented by ⁦EM Mace⁩. Demonstrating the importance of NCAM1 in NK development. ⁦SNI NK Meeting⁩ #NK2022

Antigens in MN:
📌 PLA2R
📌 EXT1/EXT2
📌 NELL1
📌 PCHD7
📌 SEM3B
📌 NCAM1
📌 FAT1
📌CNTN1
📌 NTNG1/HTRA1
📌 NDNF
📌 PCSK6

#ISNWCN

NCAM-1 associated MN - NCAM1 is highly expressed in the Brain and is associated with neuropsychiatric lupus! GlomCon Tiffany Caza

#Body Versus #Brain : New evidence for an #Autoimmune cause of #Schizophrenia

Researchers have found some people with #schizophrenia have #autoantibodies -- rather than outside threats such as viruses or bacteria - against #NCAM1 . See more... scitechupdates.com/body-versus-br…

NCAM1, CADM2, SCOC and KCNT2: 4 genes associated with #cannabis use: buff.ly/1RR9vgR

1/1 New antigen Protocadherin 7 (PCDH7) in MN is out! Unique findings:Older patients, minimal/no complement activation, heavily glycosylated protein, subnephrotic proteinuria, many spontaneous remission. Incidence- PLA2R>EXT>NELL1>PCDH7>NCAM1>SEMA3B=THSD7A jasn.asnjournals.org/content/early/…

Using serum proteomics, Jennings et al. identify NCAM1 and GDF15 as sensitive and specific biomarkers for axonal and demyelinating forms of Charcot-Marie-Tooth disease in patients and four different mouse models. bit.ly/3BknzuL

#NCAM1 : a novel autoantigen in #membranous #lupusnephritis
doi.org/10.1016/j.kint…
Tiffany Caza Chris Larsen

11/14
Here’s a table showing the clinical characteristics associated with each antigen
Sethi, 2021; Bobart et al, 2021 and Caza et al: 2021 EXT1/EXT2 and NCAM1 are associated with SLE. NELL-1 is associated with malignancy while Sema 3b is more common in children with + family hx

GWAS of 53,400 #IBS patients:

🧬6 implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6.
😰Associated with #mood and
#anxiety disorders.
IBS SNP heritability was just 5.8%.
🦠Environmental factors play a major role.

nature.com/articles/s4158…

The HGNC official name of the gene that encodes this protein is NCAM1 🙌🙌

Reference: mechanobio.info/what-is-mechan…

5/

Şizofreni hastalarının bir kısmında anti-NCAM1 otoantikoru pozitif. Şizofrenideki heterojenliği aydınlatmak için bu ve benzeri çalışmalar çok önemli 👏

Check out the expression of your favourite gene during NK cell differentiation: malmberglab.com/rnaseq/ 
(username: CD56, password: NCAM1) (Our corresponding scRNAseq resource pending..)

Dr Sanjeev Sethi Sanjeev Sethi speaks on Membranous GN #isncon22 @isncon22

Latest Antigens of MGN in Brief..
EXT1
Nell
PCHD7
SEMA3B
NCAM1

Sanjeev Sethi Renal Path Labs Umesh Khanna GlomCon Shyam Bansal Indian Society of Nephrology Mayuri Trivedi Indian Society of Renal& Transplantation Pathology @isncon22

Neural cell adhesion molecule 1 (NCAM1) is a novel autoantigen in membranous lupus nephritis ca. 2020 from Kidney International Tiffany Caza Shree Sharma Chris Larsen #Nephpearls

👉🏼 kidney-international.org/article/S0085-…

NCAM1(*_*)

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in #AML bloodjournal.org/content/133/21…

Netrin G1 is a novel antigen in membranous nephropathy.

Although rare, it adds to the list of antigens with a neural basis like NELL1, SEMA3B, NCAM1, and CNTN1.

Another brick in the MN wall 😊