#MCWNeuroradBTW 074Ans: PCNSL

#TeachingMoment on DWI bright lesions

#FOAMed #radres #MedEd The American Society of Neuroradiology ARRS British Society of Head & Neck Imaging ESNR BSHNI Trainees ESHNR Brian Dupree MCW Neuroradiology Omer Awan MD MPH Aaron Rutman, MD RadDiscord ASHNR AUR Fatima Elahi Surjith Vattoth

Indications for auto-transplant - for the oncology fellows

Myeloma 1st or 2nd remission (⬆️OS)
Chemosensitive R/R DLBCL (⬆️OS)

Rest not clear cut
PTCL in CR1 (no phase III)
MCL in CR1 (PIII ⬆️PFS CHOP induction)
R/R FL (favored for those with PFS1<24 mon)
PCNSL in CR1 or R/R

Just released online, our meta-analysis: Toxicity and Efficacy of CAR T-cell Therapy in PCNSL (n=30) and SCNSL (n=98)
-PCNSL vs SCNSL:
—>13% vs 11% grade 3-4 CRS
—>18% vs 26% grade 3-4 ICANS
—>56% vs 47% CR; both 37% CR at 6 mo ashpublications.org/bloodadvances/…

Happy to present our last results on primary and secondary CNS lymphoma at #17ICML in Lugano.

Huge thanks to Marta Crespo and the Experimental Hematology team at Vall d’Hebron Institute of Oncology (VHIO) Hematologia - Hospital Universitari Vall d'Hebron. Also, to the International Conference on Malignant Lymphoma committee for supporting our work.

#ICML2023 #PCNSL #SCNSL

Cytotoxic and immunomodulation in #PCNSL after BTK and XPO1 inhibition in xenograft mouse models. Our latest research published in Journal of Neuro-Oncology available here rdcu.be/b5JZK #openaccess Vall d’Hebron Institute of Oncology (VHIO) Hematologia - Hospital Universitari Vall d'Hebron

Looks different in immuno-deficient: Primary 🧠 #Lymphoma may lack uniform hypercellularity on #MRI & show edge enhancement & necrosis similar to tumefactive demyelination ⬇️

Bx ➕ PCNSL Before & 5 mo. s/p chemo (last pic) #radres #FOAMrad #neurorad #neuroncology #neurology

“Creation and implementation of a VASARI feature PACS-Integrated tool for PCNSL Classification” presented at American Society of Functional Neuroradiology in Maui, HA

So grateful to Dr Mariam Aboian and all my amazing colleagues/friends at @ImagineQuant!

#NeuroRad #AI #YaleRadiology Yale Radiology Residents

So proud of our amazing PGY5 Kathryn Ries Tringale helping to reinvigorate and modernize the use of #radiation for #pcnsl at #ASH22 Joachim (Achy) Yahalom Memorial Sloan Kettering Radiation Oncology MSKHemOncTrials

Now catching up @HemoncUcsf ⭐️fellow Mazie Tsang, MD, MAS, MS presentation during the UC Hematologic Malignancies Consortium discussing her work in #QOL in #PCNSL #olderadults
UCSF Helen Diller Family Comprehensive Cancer Ctr #geriheme Hematology & Oncology Women Physicians Group—HOWPG Swetha Kambhampati Rahul Banerjee, MD, FACP Vanessa Kennedy Bridget Keenan MD PhD Anna Parks

#FOAMrad #radres #neurorad #HUNSC #radiologysigns

Primary Central Nervous System Lymphoma (PCNSL)
At left axial FLAIR and coronal T2 (top)
DWI and ADC (down)
At right enhanced T1 MRI with “Notch Sign” (arrows)

While not being presented at #ASH21 we were able to show Keppra did not significantly impact HDMTX clearance in PCNSL. thanks ⁦Pallawi Torka⁩ ⁦Ilana Cypes⁩ ⁦Roswell Park Oncology Pharmacy Residency Program⁩ #oncopharm ashpublications.org/blood/article/…

The answer to yesterday’s #imagechallenge was….Primary CNS Lymphoma (PCNSL)! PCNSL is an extranodal malignant lymphoma arising in the CNS without concurrent systemic lymphoma and is primarily a non-Hodgkin/diffuse large B-cell lymphoma.

neurosurgicalatlas.com/volumes/neuror….

Presented on PCNSL yesterday. SO thankful to Kamran Mirza - کامران مرزا for this rotation. I loved it.
BIG thanks to the amazing(!!!) residents. And loved learning with Vorapat Vorapanya, MD, MPH Harith Elsiddig, MD Nolan Donahue, DO Vasily Ovechko and others! Thanks to Cullen Lilley, MD, MS, MA, MB(ASCP) for pathelective!

Come, check our poster LBA9 to learn about the safety and efficacy of CAR-T cell therapy in primary and secondary CNS lymphoma. #Tandem22 #ASTCT #CART #PCNSL #SCNSL

Weekend shift in our transplant/cellular therapy center and you see the following:
-AML/ALL
-MDS/CMML
-Myelofibrosis
-Myeloma/pPCL
-DLBCL/HL/PTCL/PCNSL/AITL/MCL
- #MultipleSclerosis /Neuromyelitis optica
#lymsm #leusm #mmsm #mpnsm #mdssm #NeuroTwitter
Hamburg, my blue pearl!

Haematologca
European Collaboration 🇬🇧 🇮🇹 🇩🇪
Thiotepa-based ASCT in SCNSL
n=134
All SCNSL: de novo or relapse (isolated/synchronous)
✔️ 3yr OS 72% PFS 61%
✔️PR/CR on MRI/PER pre ASCT have excellent outcomes after ASCT (consistent with approach in PCNSL)

Primary central nervous system lymphoma ashpublications.org/blood/article/… #lymsm #PCNSL

Lupus + Immunosuppression + Ring enhancing Lesions on image

▶️▶️🧠Primary Central Nervous System Lymphoma (PCNSL) should be considered wikem.org/wiki/Ring-enha…

Application of #AI for understanding the biology of PCNSL by ⁦Irene Dixe de Oliveira Santo, MD⁩ ⁦The American Society of Neuroradiology⁩ #ASNR22 Solving problems that we see in clinical practice!⁦Sara Merkaj⁩ ⁦Gabriel Cassinelli⁩ ⁦Yale Radiology Residents⁩ ⁦Yale Department of Radiology & Biomedical Imaging⁩ ⁦@YaleNeuroradiology⁩ #IR #NeuroIR

Congratulations Bhausaheb Bagal Tata Memorial Hospital #Hematolymphoid group showing benefit of MT-R induction and modified cytarabine Etoposide consolidation in #PCNSL at #ASH23
Hasmukh Jain Manju Sengar Lingaraj Nayak Hematology Cancer Consortium