Malignant Neutrophilia!
Last ed post of my 30's.

Netrophilia+BCR-ABL p210 = CML

Massive neutrophilia+BCR-ABL p230 = CML
Not chronic neutrophilic leukemia (CNL)

CNL
CSF3R mutation
Minimal dysplasia

Atypical CML
BCR-ABL negative!
ASXL1, NRAS, SETBP1, SRSF2, TET2
Dysplasia!

Dr. Serra MENEKAY' ın Sunumuyla KUZEY IŞIKLARI Kırım'dan Türk Dünyasına Yayılan Kadın Aydınlanması
İlgili Linkler:
1.Oturum: us04web.zoom.us/j/5044817712?p…
Toplantı Kimliği: 504 481 7712
Parola: tet1
2.oturum (21:40): us04web.zoom.us/j/71067383135?…
Toplantı Kimliği: 710 6738 3135
Parola: tet2

F. Lemmonier on Tfh lymphoma-the most fascinating lymphoma Related to clonal haemopoiesis in a sig number. Unique co-existent TET2/IDH2 mutations to drive Tfh phenotype. Complex microenvironment with clonal B-cell expansion Lysa Lymphoma developing platform design #lymsm #ICML23

TET Çevrim İçi Etkinlikleri Kapsamında
ÖLÜMSÜZ VATAN TÜRKÜSÜ ÇANAKKALE Konulu Etkinlik Planlanmıştır.
LİNKLER

1.Oturum: us04web.zoom.us/j/5044817712?p…
Toplantı Kimliği: 504 481 7712
Parola: tet1
2.oturum (21:40): us04web.zoom.us/j/71067383135?…
Toplantı Kimliği: 710 6738 3135
Parola: tet2

KUZEY IŞIKLARI Kırım'dan Türk Dünyasına Yayılan Kadın Aydınlanması Konulu Etkinlik
İlgili Linkler:
1.Oturum: us04web.zoom.us/j/5044817712?p…

Toplantı Kimliği: 504 481 7712
Parola: tet1

2.oturum (21:40): us04web.zoom.us/j/71067383135?…

Toplantı Kimliği: 710 6738 3135
Parola: tet2

Y si Taylor agrega Treacherous al track list de TET2?

Human data suggest that people w/ TET2 CH and high CVD risk may derive particular benefit from drugs that inhibit IL-1β, though mechanisms remain unclear. New study highlights a potential role for fibroblast-like cell accumulation and plaque stabilization
nature.com/articles/s4416…

#BPDCN involving the skin & harboring pathogenic TET2, ASXL1 & ZRSR2 mutations

Concurrent bone marrow biopsy was negative for OVERT morphologic/immunophenotypic evidence of involvement by a myeloid neoplasm or BPDCN

#leusm #hemepath #MedTwitter #PathTwitter #mpnsm

Prof Hartmut Dohner on oncogenes tree model in AML #hemeonc
⚡️5 branches of the tree: ASXL1, DDX41, DNMT3A , TET2 And TP53 suggesting these are the initiating events .
⚡️While ASXL1 node depends on further mutations downstream-branching , TP53 andDDX41 doesn’t .
#MHG2023 #aml

સમગ્ર ઠાકોર સમાજ માટે ગર્વની બાબત!!

ખેરાલુની ક્ષત્રિય ઠાકોર સમાજની દિકરી દ્વારા 23 એપ્રિલના રોજ સવારે લગ્નગ્રંથિથી જોડાઈ અને ત્યારબાદ આપણને સૌ ગર્વ થાય એ રીતે બપોરે ખેરાલુથી 110 કિમી દૂર અમદાવાદ ખાતે TET2 ની પરીક્ષા આપી પરત લગ્ન સ્થળે ફર્યા અને ત્યારબાદ તેમને વિદાય આપી.

Matt Jenkins from Ferrell Lab with the most popular poster describing his work on TET2 and monocyte inflammation in CH. #ASH23

Clonal Hematopoiesis(CH) in Clinical and Experimental #HFpEF

In a HFpEF patient study, TET2-mediated CH was linked to worsened diastolic dysfunction. Validation in a cohort confirmed this association.

HFpEF patients with CH and age ≥70 faced a higher 5-year CV hospitalization

ÇOCUKLARIMIZIN YETENEKLERİNİ NASIL ÖLDÜRÜRÜZ?

İlgili Linkler:

1. Oturum

us04web.zoom.us/j/5044817712?p…

Toplantı Kimliği: 504 481 7712
Parola: tet1

2.oturum (21:40):

us04web.zoom.us/j/71067383135?…

Toplantı Kimliği: 710 6738 3135
Parola: tet2

A new cause of adult-onset autoinflammation with TET2-driver and NLRC4-passenger variants 🌡️🩸

Stunning work from ⁦Ellen De Langhe⁩ and clinical and research team ⁦UZ Leuven⁩ and ⁦⁦KU Leuven⁩. nejm.org/doi/full/10.10…

Interesting #Aorta Transcriptome+DNA #Methylome

Glucose-6-phosphate dehydrogenase/G6PD S188F CRISPR rat vs WT

1509 DEG->⏫DNMT1/2, TET2/3->
⏫5-hmC ie.⏬global DNA methylation

4222 differentially methylated regions (>17 k loci)
-> 29 hypomethylated + ⏫genes->

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function biorxiv.org/content/10.110…

Results of this cohort study show that large TET2 and ASXL1 CHIP—but not DNMT3A CHIP—were associated with higher IL-6 level, indices of cardiac remodeling, and an increased risk for AF. ja.ma/3VOzLAf

Happy to share a collaborative paper with Mrinal Patnaik Terra Lasho, PhD Moritz Binder on single cell proteogenomic profiling of TET2 mutations in blood. nature.com/articles/s4137…

Very interesting !!!
TET2-Driver and NLRC4-Passenger Variants in Adult-Onset Autoinflammation
nejm.org/doi/full/10.10…

Cai et al - CHOP v CHOP-X 1L PTCL
• X guided by mutn
• eg p53 - decitabine; KMT2Dmut/ TET2
• signif ⬆️ CMR for CHOP-X
• PFS also ⬆️ but ?signif (CI overlap)
• benefit mainly in hypometh arms
Interesting data suggesting mutn guided approach maybe beneficial.
#17ICML