In the CORONA and GISSI-HF trials, statins did not improve outcomes in participants w/ HF.

In contrast, in the #JACCAdvances study by Ariela Orkaby MD MPH et al, new statin use was associated w/ reduced adverse CV events in Veterans w/ #HFpEF without #ASCVD . bit.ly/4a7zY4P #CVD

HFpEF

Quality of life (QOL) matters in HFpEF

These patients want to feel well ‼️

Enter STEP HFpEF at #ESC2023

#MedTwitter #MedEd #CardioTwitter European Society of Cardiology

HFpEF vs HFmrEF management 🏥 via #esc2023 #EBM

🔑 Clinical Trials:

🔹DELIVER (2022) and EMPEROR-Preserved (2021): SGLT2i in EF>40%
🔹PARAGON-HF (2019): ARNI vs ARB in EF>45%
🔹TOPCAT (2014): MRA in EF>45%
🔹CHARM-Preserved (2003): ARB in EF>40%

App 🔗 apps.apple.com/us/app/cardiac…

🔴The 5 pillars for HFrEF
🔴The 5 pillars for HFpEF
🔴The 4 pillars for diabetic CKD
🔴The 4 Pillars for AF😁

Summary by Ahmed Mohsen
#CardioTwitter #medx #medEd #MedTwitter #MedEd #cardiotwitter #FOAMed #CardioEd #Cardiology #MedEd #ENARM #cardiotwiteros #meded #cardiology

🔴 Catheter Ablation Versus Medical Therapy for Atrial Fibrillation in Patients with HFpEF: A Systematic Review and Meta-analysis

heartrhythmjournal.com/article/S1547-…
#cardiology #CardioTwitter #CardioEd #MedEd #cardiotwiteros #medtwitter

Fascinating #labmeeting by Thassio Mesquita on #fibrosis in #HFpEF . Targeting FOXO1 in #fibroblasts improves #diastole and reduces #VT #inducibility in 2-hit mice. Smidt Heart Institute at Cedars-Sinai Cedars-Sinai Academic Medicine

HFpEF

Heart Failure with preserved ejection fraction

Subscribe 👇
youtube.com/@pgmedicine2023

Cost-Effectiveness of Medical Therapy for Heart Failure With Mildly Reduced and Preserved Ejection Fraction

For patients with heart failure, MRA was of high value, SGLT2i was of intermediate value, and ARNI was of low value in both HFmrEF and HFpEF

jacc.org/doi/10.1016/j.…

Harriette Van Spall, MD MPH Almost 60% of patients with HFpEF suffer from chronotropic incompetence while being on beta-blockers

x.com/FH_Verbrugge/s…

💶💵 Cost-Effectiveness of Medical Therapy for HFmrEF/HFpEF

💊MRA
💊💊MRA + SGLT2i
💊💊💊 MRA + SGLT2i+ARNI

↗️ in life years of HFmrEF/HFpEF👥
💊1.04/0.99
2️⃣💊1.58/1.54
3️⃣💊1.80/1.77

💊MRA therapy ICERs of $10,000 per r
QALY in both subgroups
💊💊ICER $113,000 per QALY in the…

5 pillars for HFrEF
5 pillars for HFpEF
4 pillars for diabetic CKD
4 Pillars for AF😁

More Data Support Semaglutide for Obesity-Related HFpEF, Regardless of Diabetes Diagnosis

A pooled analysis from two industry-funded trials shows improved obesity and symptoms of heart failure with preserved ejection fraction. jwat.ch/4a2rJHd

Vlad Zaha #CardioTwitter

Interesting analysis from PARAGON: As ejection fraction moves away from lower levels towards a higher range, patients with HFPEF tend to experience hypotension more frequently, leading to a higher risk of fatal and nonfatal events. #cardiotwitter #Cardiology #CardioEd

🔺There is no high-quality evidence to support use of #BetaBlockers in #HFpEF ncbi.nlm.nih.gov/pmc/articles/P…
🔺In absence of other indications, consider withdrawing BBs from HFpEF regimen, especially in setting of #chronotropic incompetence (ie chronotropic index <0.62 during max #CPET )

HFpEF Management in one slide 👇🏼

#MedTwitter #CardioTwitter #ACC2024 American College of Cardiology

New post-doc position available on inflammation in #HFpEF in our lab within CARIM

🖥️vacancies.maastrichtuniversity.nl/job/Maastricht…

Happy to share my experience as member of our team!

#cardiotwitter #younghfa #jobseekers #vacancies

#HFpEF presented by #NadiaDridi from Dept. of Cardiology, Zealand University Hospital

diagnostic, treatment and prognosis

Introducing us to miss HEFFENPFEFFER and how to treat her 🩺💊

How easy is to miss HFpEF (and related complications)?

A (real) case-based🧵