The role and mechanism of TXNDC5 in disease progression dlvr.it/T4y0JZ #FrontImmunol

🔬 ¿Cómo influye la proteína #TXNDC5 en el almacenamiento hepático del escualeno? Personal investigador de CIBEROBN y la UCC unizar estudian este misterio con edición genética.

🔗ciberisciii.es/noticias/estud…

eurjmedres.biomedcentral.com/articles/10.11…

'In addition, TXNDC5 can interact with peroxidized Prx2 and participate in redox signal transduction.'

eurjmedres.biomedcentral.com/articles/10.11…

'Ero1 mainly interacts with archetypal PDI family members, whereas TXNDC5 mainly interacts with peroxiredoxin-4 (Prx4).'

jhep-reports.eu/article/S2589-…

'We report that 4 members of the PDI family (PDIA4, PDIA3, P4HB, and TXNDC5) are specifically upregulated in ZZ-AATD liver samples from adult patients.'

eurjmedres.biomedcentral.com/articles/10.11…

'TXNDC5 has three Trx-like domains, which can act independently to introduce disulfide bonds rapidly and disorderly.'

'TXNDC5 is abnormally expressed in various diseases, such as cancer, rheumatoid arthritis (RA), etc.'

eurjmedres.biomedcentral.com/articles/10.11…

'Hydrogen peroxide generated during Ero1α–PDI interaction can act on the catalytic oxidation reaction between Prx4 and TXNDC5 to accelerate protein folding.'

eurjmedres.biomedcentral.com/articles/10.11…

'Thioredoxin domain-containing protein 5 (TXNDC5) is a member of the protein disulfide isomerase (PDI) family.'

'It can promote the formation and rearrangement of disulfide bonds, ensuring proper protein folding.'

eurjmedres.biomedcentral.com/articles/10.11…

'Both PDI and TXNDC5 can catalyse the formation of regulatory disulfide in endoplasmic reticulum oxidoreductase 1α (Ero1α), thereby preventing excessive oxidative stress caused by excessive H2O2 production.'

eurjmedres.biomedcentral.com/articles/10.11…

'Similar to most members of the PDI family, TXNDC5 can catalyse the formation and rearrangement of disulfide bonds, thereby promoting the correct folding of proteins.'

'In addition, the CxxC motif plays a key role in this process.'

eurjmedres.biomedcentral.com/articles/10.11…

'It can protect cells from oxidative stress, promote cell proliferation, inhibit apoptosis and promote the progression of disease.'

'Aberrant expression of TXNDC5 in different diseases suggests its role in disease diagnosis.'

Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release dlvr.it/T4nRZ4

Encuentran nuevas funciones y beneficios del escualeno, un componente del aceite de oliva CIBEROBN UCC unizar 🫒🛢️ #escualeno #aceitedeoliva #TXNDC5   elmedicointeractivo.com/encuentran-nue…

Varios equipos del CIBERESP y la Universidad Zaragoza estudian el papel de TXNDC5 en el almacenamiento hepático del escualeno dlvr.it/T5gkKr

New Research: The role and mechanism of TXNDC5 in disease progression: Thioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the… frontiersin.org/articles/10.33… #immunology