Our new manuscript on LRRK2 activation with Noma Francesca and Dario ASAP LRRK2 Central. We reveal a novel LRRK2 kinase activation mechanism via spatial regulation and protein non-symmetric tetramerization (dimer of asymmetric dimers). See animation (credit Norman Luo)

Tetramerization of BEB-Doped Phenalenyls to Obtain (BE)8-[16]Annulenes (E = N, O)

J. Am. Chem. Soc. #Chemistry #Chemed #Science #TechnologyNews #news #technology #AcademicTwitter #AcademicChatter

pubs.acs.org/doi/10.1021/ja…

Predicting the Stability of p53 Tetramerization Domain Mutants

New paper out!

'Structural Basis of Mutation-Dependent p53 Tetramerization Deficiency'

A great experimental-computational work in collaboration with our colleagues from CIBIO - UniTrento.

mdpi.com/1422-0067/23/1…

Our latest publication by Alexander Scholz is available online! 🧪 J. Am. Chem. Soc.

'Tetramerization of BEB-Doped Phenalenyls to Obtain (BE)8-[16]Annulenes (E = N, O)'

Thanks for the nice collaboration Dr Cate S. Anstöter!

pubs.acs.org/doi/full/10.10…

This is the best cover slide to a literature talk I've seen.

Ethylene tetramerization GRINDHOUSE.

(Covering the Jerzy Klosin/DOW double header in the Organometallics ASAP)

I'm excited to share our latest preprint on how kinesin-5's unique tetramerization and tail domains enable it to crosslink and slide microtubules. Congrats to collaborators Jawdat Al-Bassam, Scott Forth, Gary Brouhard, and Steve Rosenfeld, and especially to Malina Iwanski!

ZapA tetramerization is required for midcell localization and ZapB interaction in Escherichia coli biorxiv.org/content/10.110…

'A Guardian's Window' shows the p53 tetramerization domain. p53 (aka the Guardian of the Genome) is a protein that determines whether a cell lives or dies, esp. after DNA damage. Commissioned by Francisco J. Sánchez-Rivera for Scott Lowe Lowe Lab #SciArt

Back in 2016, we reported DNA-dependent tetramerization of the glucocorticoid receptor. Its most closely related 'sibling', the mineralocorticoid receptor, appears to be even weirder! Check out this pre-print led by Diego Alvarez de la Rosa and Gordon Hager
biorxiv.org/content/10.110…

Modeling suggests that glycan at Asn241 is structurally and functionally important due to its close proximity to the BChE tetramerization domain and the active site gorge. What about wet biochemistry? bit.ly/2iw78HN

Tetramerization of BEB-Doped Phenalenyls to Obtain (BE)8-[16]Annulenes (E = N, O) (WagnerLab, Alexander Scholz, Dr Cate S. Anstöter): pubs.acs.org/doi/full/10.10… (@J_A_C_S).

Prebiotic Chemistry of HCN Tetramerization by Automated Reaction Search (Anoop) doi.wiley.com/10.1002/chem.2…

Piers' Borane-Induced Tetramerization of Arylacetylenes (Gellrich) #OpenAccess through #ProjektDEAL onlinelibrary.wiley.com/doi/10.1002/ch…

What's new in Organometallics Characterization of Cr-Hydrocarbyl Species via Pulse EPR in the Study of Ethylene Tetramerization Catalysis, from Oyala, Agapie, and colleagues. Learn more here: doi.org/10.1021/acs.or…

The massive structure of type III ATP synthase, a symmetry-deviated dimer that induces membrane curvature through tetramerization (PDBid 6yny). This baby weighs more than 2000 kDa! Solved by Alexey Amunts lab, Nature Communications. Rendered w #ProteinImager 3dproteinimaging.com/protein-imager…

This paper was submitted on Valentines day in the Year 2020 and got accepted few days back. Congratulations to Johnson and Aaadi for their interesting and nice co-authored paper.
Stability of p53 oligomers: Tetramerization of p53 impinges on its sta... sciencedirect.com/science/articl…

🌱Job opportunity
Open PhD position (m/f/d) on the evolution of MADS-domain protein tetramerization during the transition of plants to land
in Günter Theißen's lab Universität Jena
more info: jobs.uni-jena.de/jobposting/ac0…

Piers' Borane (@Wpiers1) Induced Tetramerization of Arylacetylenes (@GellrichUrs): onlinelibrary.wiley.com/doi/10.1002/ch… (@ChemEurJ).

Excited to see the last part of my PhD work finally out in Science Advances. Thanks to everyone being involved!

A stapled peptide mimetic of the CtIP tetramerization motif interferes with double-strand break repair and replication fork protection advances.sciencemag.org/content/7/8/ea…