#HeartFailure patients with very high NTproBNP show trend for HARM with #vericiguat treatment vs placebo ☠️ 🏥

Too sick to benefit? Interesting subanalysis from #VICTORIA trial in European Society of Cardiology Journals #EJHF

📄 by Michele Senni burkert pieske et al

SAFE: Blood Pressure and Safety Events With Vericiguat in the VICTORIA ahajournals.org/doi/10.1161/JA… Nicolas Manito Alfonso Valle Enrique Santas Javier Torres Diego Segura-Rodriguez Fernando de la Guía @marisa1109 SABOURETCardiologist Italo Kumamoto Giuseppe Galati Manuel Méndez rafavidalperez @ICyFA-SEMI

Wow! Impressive & broad-spanning release of the #ESC guidelines #HeartFailure2021 . Full guidelines at #ESC 2021

#HF rEF 'quadruple Rx' now SoC!
✅ #SGLT2i , #RASi / #ARNI #BB , #MRA (all I)
✅ #Vericiguat (IIb)

#HF mildly-reduced EF (re-termed)
✅ #RASi / #ARNI , #BB , #MRA (all IIb)

Eligibility for vericiguat in a real-🌏 #HF 👥 according to trial, guideline and label criteria: 🇸🇪 Heart Failure Registry
👉 estimated eligibility for vericiguat was
📌21% according to the #VICTORIA trial criteria
📌 47% according to guidelines
👉prior HF 🏥 was the most…

What’s everyone’s experience with Vericiguat? Any practical pointer? #CardioTwitter
James Januzzi Jr MD Jonathan Davis, MD, MPHS Indranee Rajapreyar Andrew J Sauer MD Susan Joseph MD Ryan J Tedford MD Dharini Ramu Amin Yehya, MD, MS, FACC, FHFSA Ashwin R Jason N. Katz Shashank Sinha, MD, MSc, FACC, FAHA Gregory Macaluso Nikhil Narang, MD Dr Amanda Vest Anu Lala-Trindade

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⚠️ Vericiguat in Heart failure therapy: the fifth card‼️

European Society of Cardiology Journals Soc Esp Cardiología SACardiología Asociación Cardiología Clínica SEC Bayer España Steve Greene Vanessa Blumer, MD Alexander Hajduczok, MD 🇺🇦🙏 Jason N. Katz Michelle Kittleson MD PhD

academic.oup.com/eurheartjsupp/…

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What's NEW in Management of #HeartFailure2021 ❓❓

🔸Vericiguat MAY be considered in worsening HF (2b B)

🛑 Omecamtive Mecarbil is not licensed for use in HF

European Society of Cardiology Shelley Zieroth Mamas A. Mamas HFAPresident
#HFA_ESC #CardioTwitter

Bayer_Vericiguat_MoA_DE_V01 - NEU.mp4 on Vimeo player.vimeo.com/video/585312433

🔥 Beautiful recent review on known mechanisms of #HF #therapies
🍀 Complementary actions
🔬 Need for further research about #SGLT2i #Vericiguat #Omecamtiv #ARNI
Javed Butler CVR Tomasz Guzik Izza Shahid Gregg Fonarow MD James Januzzi Jr MD Giuseppe Biondi-Zoccai Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Kamala Tamirisa MD Ritu Thamman MD

Drugs for Heart Failure (HFrEF):

1. Bisoprolol
2. Ramipril or ARNI Entresto
(Cadesartan if intolerant to ACEi)
3. SGLT2 inhibitor (e.g. dapagliflozin).
4 . MRA e.g. spironolactone
5. Ivabradine
6. Vericiguat
7. Digoxin
8. Hydralazine and isosorbide dinitrate
9. Omecamtiv…

📌Practical Patient Care Considerations w/ Use of #Vericiguat After #Worsening #HeartFailure Events

#CardioTwitter #CardioEd

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📌Soluble Guanylate Cyclase Stimulators in 👥w/ #HFrEF Across the Risk Spectrum

#CardioEd #CardioTwitter #Worsening #HeartFailure #Vericiguat

John Dubay Shariq Shamim Mehrdad Saririan⚕️ I have never prescribed vericiguat in Canada

HEART FAILURE IN TYPE 2 DIABETES:THERAPEUTIC ALGORITHM v2.0 redGDPS Diabetes now including the fifth drug Vericiguat and Finerenone in DKD.Heart Failure is 2-5 times more frequent in people with diabetes,where comorbidity is the rule.Avoiding clinical inertia. In HF time matters.Act now!

#ACC20 / #WCCardio | #VICTORIA trial: Patients with worsening #heartfailure and reduced EF who received #vericiguat had a significantly lower rate of CV death or HF hospitalization compared witht hose receiving a placebo.

Vericiguat is now a member of the academy.

🔎find out the role of #vericiguat in #HF management on European Society of Cardiology Journals 🔔 @_ANMCO position paper, led by past-President Prof Colivicchi, a summary on 🔬mechanisms of actions, clinical evidence &🩺practical indications
Leonardo De Luca, MD, PhD, FACC, FESC
Alberto Aimo
👇
academic.oup.com/eurheartjsupp/…

In patients with worsening #HFrEF , vericiguat significantly decreased NT-proBNP levels compared with placebo.

Learn more about this study & other research highlights in our annual report: thecvc.ca/patient-center…

Justin Ezekowitz Cindy Westerhout, PhD Yinggan(Gray) Zheng UAlberta Med & Dent

Wait is over now.

#HeartFailure2021 about to start. So excited about treatment guidelines for HF. What will be the status of #ARNI #SGLT2i #VERICIGUAT #OMECAMTIVEMECARBIL
European Society of Cardiology EHJ Editor-in-Chief
Mamas A. Mamas Dr. Purvi Parwani Aamisha Gupta, MD, FACC (she/her)
#HFA_ESC

📌 #Vericiguat in #HeartFailure w/ a Reduced Ejection Fraction: Patient Selection & Special Considerations
#CardioEd #CardioTwitter