CalTrack 🔥 Kemdirịm

Thanks to everyone who joined us for the last OpenEEMeter technical working group meeting.

Thanks especially to James Fenna for his presentation on adapting CalTRACK for the U.K. and internationally.

The next meeting is on April 4th. We look forward to seeing you there!

Join us on November 22nd, 2022! LF Energy and the OpenEEmeter project team are pleased to re-launch the CalTRACK working group to incorporate updates to the methods and code and formally enfold CalTRACK under the OpenEEmeter project umbrella. caltrack.org/technical-work…

This is the first slide, predating the CalTRACK process, that introduced the wild idea of an energy efficiency 'meter.'

We have come a rather long way!

How CalTRACK works art by our new awesome team member Mia Oppelstrup!

Thanks to all who attended the most recent CalTRACK working group meeting. A video of the meeting is available on the CalTRACK website: bit.ly/3IDwDQD. The next meeting is March 7th at 1:00 PM Pacific Time. Looking forward to seeing you there!

The next OpenEEmeter working group meeting is coming up! We're making progress and are excited to share our results. Join the conversation on Tuesday, June 6th. See what we've been up to here: bit.ly/3ZypS8p

The next OpenEEmeter Working Group meeting is coming up tomorrow!

Looking forward to seeing you there.

bit.ly/3ZypS8p

The next OpenEEmeter working group meeting is coming up! Join us on Tuesday, April 4th. bit.ly/42LhgOb

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We presented some biology in CalTrack alongside our code. This is a short thread to dig into that data and what it might tell us about different forms of hypertrophic cardiomyopathy.

ahajournals.org/doi/10.1161/CI…

Reminder: the next OpenEEmeter 2.1 working group meeting is coming up tomorrow, March 7th, 1PM PT.

This working group is comprised of many of the leading users of these methods and code. Come join the process!

Register here: bit.ly/3ZypS8p

Blessed to have competed against some of the fastest athletes in Hawaii at the CalTrack Ruby Tuesday Hawaii Invitational. Received the award for Outstanding Girls Runner Events for my 100m and 200m races.

Ever wonder how the CalTRACK Hourly Methods actually work? recurve.com/how-it-works/c…

In CalTrack we found that Mavacamten has some benefit in correcting calcium transients in a hypertrophic cardiomyopathy variant of the thin filament. However, we didn't see complete resolution of the cellular phenotype.

CalTrack can be used in a variety of model systems and cell sources. Ranging primary cardiomyocytes, iPSC-CMs, organoids, and 3D tissues. You can analyse data collected using ratiometric or non-ratiometric indicators. Analysis can be performed on movies, line scans, and PMT data.

CalTrack can also detect abnormal calcium transient events such as early and delayed after depolarisations.

We have also used CalTrack to define changes in calcium transient in primary cardiomyocytes due to pharmacological agents.

We have demonstrated that CalTrack can also be used effectively in human iPSC-CMs to define HCM phenotypes and responses to the pharmacological agent Mavacamten.

We have used CalTrack to define changes in calcium transients observed in primary cells due to genetic variants that cause hypertrophic cardiomyopathy.