Researchers present a platform for cardiac tissue cultivation with 3D ring-shaped cardiac tissues generated from human stem cell-derived cardiomyocytes. elifesciences.org/articles/87739…

Didn't skip a beat. Established a CRISPRi-based hiPSC tool to model telomere length & show short telomeres w/ poor cardiomyogenic potential & cardiomyocytes w/ short telomeres are functionally impaired & vulnerable to stress. Incredible work Shambhabi Chatterjee !!
doi.org/10.1007/s00018…

Researchers present a platform for cardiac tissue cultivation with 3D ring-shaped cardiac tissues generated from human stem cell-derived cardiomyocytes. elifesciences.org/articles/87739…

[1:1]
The potassium channel–activating ability of cilantro extract has been shown to help to repolarize ventricular cardiomyocytes.

[1:1]
The potassium channel–activating ability of cilantro extract has been shown to help to repolarize ventricular cardiomyocytes.

[2:1]
Naringin is able to suppress mitochondrial reactive oxygen species (ROS) production and mitochondrial dysfunction in cardiomyocytes (cardiac muscle cells) exposed to fructose.

[2:1]
Naringin is able to suppress mitochondrial reactive oxygen species (ROS) production and mitochondrial dysfunction in cardiomyocytes (cardiac muscle cells) exposed to fructose.

[2]
Nicotinamide riboside efficiently rescues NAD+ synthesis in the heart and stimulates glycolysis (energy production) in cardiomyocytes (heart muscles).

Richard J Oparil Erin Elizabeth Health Nut News 🙌 When the COVID 💉 mRNA for the spike protein goes into the 💪 which is surrounded by 🩸 vessels,
it gets into the blood stream.
There it embeds in the endothelium and cardiomyocytes, causing amyloidosis, (bent proteins in the 🫀)
One of several papers on the amyloidosis of spike.

Une thérapie génique qui régénère les cardiomyocytes après une crise cardiaque
rtflash.fr/therapie-geniq…

Independent compartmentalization of functional, metabolic, and transcriptional maturation of hiPSC-derived cardiomyocytes dlvr.it/T69KJK

What is happening in these cardiomyocytes?

Autopsy heart, areas of blue/grey discoloration within the cytoplasm of cardiomyocytes - also (not pictured) scattered foci of lymphocytes within myocardium

Clin: suspicion sarcoid

This study by Dr. Juliana Hernandez and team including Drs. Donald Bers & Bence Hegyi reports differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in #cardiomyocytes from obese diabetic HFpEF model. UC Davis Pharmacology

💡 bit.ly/4dmrZDR

Just planted in DMM 🌳

In silico study of the mechanisms of hypoxia and contractile dysfunction during ischemia and reperfusion of hiPSC cardiomyocytes

forest.biologists.com/landscape/?id=…

RNA-seq 🧬analysis proved advanced maturation of hiPSC-derived cardiomyocytes, similar to adult human development. 📈

Correction to: Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts ahajournals.org/doi/abs/10.116…

When ipsc cardiomyocytes became feasible, the question became how to use them for screening. Every model that has emerged has had its own flaws. I think this is one of the best models yet, from an HTS perspective. Now to get them fully matured. elifesciences.org/articles/87739…

Yap is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates Expression of Ctgf in Cardiomyocytes. biorxiv.org/cgi/content/sh… #biorxiv_pharma

This study reports continuing investigations into cell-cycle progression in cardiomyocytes of fetal pigs, using a model of myocardial infarction in test animals. doi.org/10.1093/stmcls…

Une thérapie génique qui régénère les cardiomyocytes après une crise cardiaque - rtflash.fr | tregouet.org rtflash.fr/therapie-geniq…