สรุป mitosis

เยื้อหุ้มนิวเคลียสโผล่มาในระบบเมื่อไร สารพันธุกรรมจะอยู่ในรูป chromatin [interphase,telophase,cytokinesis] นอกนั้นอยู่ในรูป chromosome หมด [นับเป็น 2 chromatid ตั้งแต่ dna rep,chromatid เดียวจะอยู่ช่วง annaphase (แยก sister) เป็นต้นไป]

ที่พิมพ์มาไม่รู้ถูกมั้ย 55555

One ovary, two tumors!

1- Benign Brenner: Smooth contoured nests of bland transitional epithelium in fibromatous stroma. Oval, grooved nuclei.

2- Metastatic Well-differentiated neuroendocrine tumor (NET): Organoid tumor cell nests w/ round nuclei & “salt and pepper” chromatin.

I can be found on head, neck, abdomen and elsewhere

I have nested architecture and salt and pepper chromatin

INSM1 +, Pancytokeratin -, GATA-3 +

Who am I?😵‍💫

#pathagonia #pathx #endocrinex #medx #surgpath #medicine #surgonc #gensurg #surgery #pathtwitter #endox #medicalstudent

NIG offers Postdoctoral Fellowship:
bit.ly/49oGIv1
If you are interested in live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions, please DM me!
bit.ly/3m6GG8y
bit.ly/390MHwZ

#GIPath classic
HSV esophagitis
Remember the 3 Ms of HSV:
Ⓜ️ultinucleation
Ⓜ️argination of chromatin (glassy nuclei)
Ⓜ️oulding of nc
When you 👀 esophageal ulcer check for infection
HSV affects keratinocytes (check ulcer edge, superficial layers)
CMV freq affects endothelium,

Multi-omic analyses reveal a differential contribution of chromatin-associated PP1 holoenzymes to mitotic exit and G1 re-establishment. biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Thrilled to announce that I will be joining UPenn Dept of Biochem & Biophys as an Assistant Professor in Jan. 2025. The Tvardovskiy Lab at Penn Epigenetics will investigate the molecular mechanisms underlying epigenome misregulation during aging and develop mass spec tools to advance chromatin research.

Our review is now online! We discuss what we know (and what we don't know) about 'Mechanistic drivers of chromatin organization into compartments'. See our discussion of compartment interval sizes and our proposed multiple compartment 'flavor' model. sciencedirect.com/science/articl…

It's out! BAZ2A forms an active compartment that protects repressive chromatin via phase separation. Weak RNA binding to BAZ2A promotes condensates whereas strong RNA binders impair them while promoting BAZ2A association to chromatin.
sciencedirect.com/science/articl…

Seeking someone looking for a two-year postbac position to get my group up and running at Yale University! We will be utilizing chromatin tracing and other multiplexed imaging approaches to study the relationship between 3D genome organization and epigenetic memory in embryos!

What if Google Maps worked inside cells?

Chromatin tracing is a spatial genomics method that acts like a GPS for important parts of DNA. Bogdan Bintu + team are using it to pinpoint more than 1,000 locations in DNA to uncover the 3D structure of DNA

... and that's a Wrap !!!
Defended MS thesis ✅

Extremely grateful to SrimontaGayen_Epigenetics lab, for allowing me to work in his group and all the past and present members of Chromatin, RNA and Genome lab.

have my kids sir, take my dna, take my deoxyribonucleic acid, take my chromatin threads, take my mitochondria, take my oxygenated blood cells, take all of it.

Our new paper about the structural mechanism by which RAD51 assembles at double-stranded DNA break sites on chromatin has been published in Nature!
doi.org/10.1038/s41586…
#CryoEM #Nucleosome #RAD51 #DNArepair

“Soccer ball” nuclei (speckled chromatin) seen on FNA of a sella turcica brain mass - “Pituitary Adenoma”.

Merkel cell carcinoma: small metastasis in a lymph node. Very nice cellular contrast on H&E alone. Salt-and-pepper chromatin. #RealLifeDermpath #dermtwitter #dermpath

Congratulations Sten Sten Linnarsson and co. for your work defining the regulatory network of brain development
nature.com/articles/s4158…

“Chromatin accessibility during human first-trimester neurodevelopment”, across the whole brain. By Camiel Mannens Sten Linnarsson Danielle & colleagues

nature.com/articles/s4158…

Salt and pepper chromatin, small round blue cells, pseudo rosettes 🏵️