Our new paper about the structural mechanism by which RAD51 assembles at double-stranded DNA break sites on chromatin has been published in Nature!
doi.org/10.1038/s41586…
#CryoEM #Nucleosome #RAD51 #DNArepair
Looking for an exciting new start in #DNArepair research? We are seeking a talented Research Assistant to work on diverse, cutting-edge projects in the DNA damage response arena. Come join us! Cambridge University CRUK Cambridge Institute jobs.cam.ac.uk/job/39352/
Our lab's latest is now out on BioRxiv. In this work we set out to understand how 'shieldin' regulates #DNArepair , focusing on its physiological function in B cells & pathological contributions to BRCA1-mutant cancers. Some background & take-home msgs (1/) biorxiv.org/content/10.110…
👋🏿🏖️Our August issue's live!
Cover: human body #spatialatlas
Read:
👉Perspective on Human BioMolecular Atlas Program (HuBMAP)
👉🏼Turning point: Nancy Kleckner
👉🏽🔬on #lipiddroplet #autophagy , #mitochondria #DNArepair , #reprogramming , #migrasome formation, #neuroprotection & more!
go.nature.com/47wQsnh
Glad to present the second part of my thesis project done with The He Lab! Using #CryoEM , we visualized how DNA-PKcs adopt different intermediate states during NHEJ #DNArepair and how a scaffolding factor, PAXX, stabilizes the complexes. Please check science.org/doi/10.1126/sc…
Please RT! The 2nd ‘Genome Instability: Discovery to Personalized Medicine’ meeting in #Philadelphia is on Nov 3rd! Focusing on #DNArepair topics it spans basic research to drug development to clinical trials. Abstracts due Sept 15th! See link to register! noncredit.temple.edu/genomeconferen…
RAD51がクロマチン上で二本鎖DNA切断部位に集積するメカニズムを、クライオ電子顕微鏡を用いて明らかにしました！
doi.org/10.1038/s41586…
#CryoEM #Nucleosome #RAD51 #DNArepair
A team led by MSK’s Agnel Sfeir uncovers MMEJ role in #DNArepair : It is not just a backup but the last-ditch repair pathway during mitosis. A protein, RHINO, plays a critical role in confining MMEJ during mitosis & directing polymerase theta to DNA breaks. bit.ly/3pLyagO?utm_ca…
🐭 DNA methylation age in Ercc1, LAKI, Polg, and Xpg mouse progeria models. Ercc1 mice, with DNA repair deficits, show significant epigenetic aging, mirroring results observed in humans. Exciting link between DNA repair and epigenetic clocks. #AgingScience #DNARepair
🧬🛠️ We had an amazing time at the Mammalian DNA Repair GRC in Ventura, CA. Fantastic presentations and discussions at a great location. 🙏 to Patricia Opresko, PhD and Roger Greenberg for organizing. Can't wait for the next one! Gordon Research Conferences #DNARepair
It’s official, Dr. Sancar has donated his Nobel medal to UT Dallas
UTD Natural Sciences & Math
#dnarepair
Glad to share our work on #DNAdamage & #immuneactivation in #SCLC at EACR-AACR-SIC conference on #Immune responses & #DNARepair . Have worked for over 6yrs looking into this fascinating interplay of #immunology #DDR in #lungcancer & how it can be exploited to treat #SCLC 🧵1/6
Another great GRC on DNA damage repair in the books. I had a great time presenting my research and making new DNA repair friends! #LGTBQinSTEM #DNArepair
Congratulations to Aoibhín Woods on the presentation of her undergraduate research project on #DNArepair and #metabolism in #lungcancer Trinity College Dublin Trinity St James's Cancer Institute at #EAI2024 News IACR EACR AACR 👩🔬🔬👏 #EAI2024 SciencetoClinic #ProudSupervisor #thefutureisbright #LCSM
New review out on genome maintenance under physical constraints, a tour de force by PhD student Vincent Spegg. Many thanks to Evi Soutoglou and Philipp Oberdoerffer for the opportunity. #DNARepair #Telomeres #ALT #Condensates #Mechanobiology #OpenAccess link.springer.com/article/10.100…
It would be such a great opportunity to share my work in a plenary lecture at the EMGS annual meeting!
The winner is determined by voting, so please retweet and share! #DNAmy #WomenInSTEM #DNArepair
🧬Hoy lanzamos #ConoceSEG donde os iremos presentando a los componentes de la Sociedad Española de Genética @SEGenetica
Iniciamos con nuestra presidenta María Teresa Roldán Teresa Roldan, Catedrática de la Universidad de Córdoba Camilo Andrès Correa
#epigenetica #cancer #DNArepair
