Want to hear about inflammatory ILC2 origins but missed my talk? Come find me at poster session this afternoon B190. AAI #AAI2024

$CRVS #soquelitinib Ph1 trial for atopic dermatitis w/ upstream MoA that stops #ILC2 , #Th2 , #Th17 .
If successful, major AD drugs worth Billions at risk:
$SNY $REGN Dupilumab
$GSK Mepolizumab
$AZN Benralizumab
$PFE Fezakinumabn
$NVS Omalizumab Ligelizumab

x.com/conradenge9805…

Các nhà nghiên cứu tại City of Hope đã phát hiện ra một loại tế bào miễn dịch trong cơ thể con người có thể tiêu diệt thành công bệnh ung thư.

Các tế bào - được gọi là tế bào bạch huyết bẩm sinh loại 2 của con người (ILC2) - được biết là rất quan

$CRVS oral ITK inhibitor #soquelitinib in Ph1 atopic dermatitis trial
Knocks out #Th2 , #Th17 and #ILC2 cells, stopping cytokines (IL-4/5/13). Novel upstream approach reduces multiple inflammation pathways at once, that takes ~8 AD drugs to do now
$SNY $REGN $GSK $AZN $LLY $PFE

New immune cell #ILC2 (2011) plays central role in atopic dermatitis.

ITK found in ILC2 + $CRVS #soquelitinib inhibits ITK!

Only drug in AD trials that can affect ILC2 directly. Should result in reduction of downstream steps in AD progression that takes multiple other drugs now

$CRVS oral ITK inhibitor #soquelitinib stops #ILC2 , #Th2 , #Th17 cells upstream and downstream cytokines (IL-4, IL-5, IL-9, IL-13, IL-22, IL-26, IL-31, IL-17A)

Novel MoA offers MANY advantages over approved monoclonal antibody (mAbs) drugs targeting only 1 or 2 cytokines.

#ILC2 play a central role in atopic dermatitis (AD), releasing inflammatory cytokines.

Cytokine profile of healthy v eczema (AD)

$SNY $REGN #Dupilumab blocks only IL-4/13 signals
$CRVS #soquelitinib stops ILC2, #Th2 , #Th17 upstream and should bring more ILs to normal levels!

Bon jour! Sa va? #lausanne #universitelausanne #eosinophils #macrophages #ilc2 #microglia #Alzheimers #obesity #inpp5d #inppl1 #shipi

Iron regulates the metabolism and effector functions of ILC2s in murine and humanized models of ILC2-dependent allergic asthma Science Translational Medicine
science.org/doi/10.1126/sc…

【講師紹介⑤】茂呂和世先生

茂呂和世先生は、ご自身が同定された免疫細胞である2型自然リンパ球(ILC2)を用いて、ILC2の分化機構などの基礎研究から、ILC2をターゲットとしたアレルギー性疾患や自己免疫疾患の創薬開発に向けた応用研究など幅広い試みをされています。
#wing44

Fibroblast diversity in #Arthritis -/+TNF Antibody/IL17A antibody
⏫CD200+FGFR2+CDH11hiCol12A1hi fibroblast during Inflammation Resolution

in silico Cd200r1 (high on pre-solving type 2 innate lymphoid cell/ILC2) KO using Dynamo

#Visium #SpatialTranscriptomics analyzed with

Nov '23 paper $CRVS for ITKi potential in autoimmune diseases (atopic dermatitis, asthma, etc) mentioned #ILC2 !

#dupilumab only blocks receptor for IL-4/13

Soquelitinib upstream can stop ILC2, Th2, #Th17
and downstream cytokines IL-4/5/13/17, TARC

biorxiv.org/content/10.110…

Looking forward to contributing our work with Johannes U Mayer & Olivier Lamiable on skin DC & ILC2 to the Skin Immunology Session at #EAAC2023 ! Such an honour to be here and so much to learn on everything #allergy

免疫応答における性差の分子機構を説明する興味深い研究成果

男性ホルモンであるアンドロゲンは皮膚ILC2に発現する受容体に作用し、GM-CSF産生を介した樹状細胞の機能制御を減弱させる

その結果、雄マウスでは皮膚常在菌や病原体に反応するT細胞が雌よりも抑制されている
science.org/doi/10.1126/sc…

An important article for the #asthmatic : Progesterone amplifies #allergic inflammation and airway pathology in association with higher lung ILC2 responses (Shubbanshi Trivedi Veterans Affairs ):

ow.ly/RbPs50REByC

#ArticleinPress #Asthma #Hormones

Piezo1 channels are induced by allergen and cytokine encounter as activation decreases ILC2 effector functions and development of airway hyperreactivity in a KLF2-dependent manner JExpMed
doi.org/10.1084/jem.20…

Mouse scRNA-seq 2.3M cells, 17 tissues finds sex-biased immune gene expression & immune cell populations (ILC2) were modulated by androgens, w/ risk gene enrichment in antigen presentation for sex-biased diseases nature
nature.com/articles/s4158…

what an interesting Piezo work...

activation of mechanosensitive Piezo1 channels supress ILC2 functions in humans and mice.

Decreased GATA3 levels in cutaneous ILC2 lead to a divergent RORγt fate-mapped subgroup accumulates around the hair follicle dermal papilla region via integrin α3β1 upregulation Developmental Cell
cell.com/developmental-…

'Discover the crucial role of IL-10 producing ILC2 in asthma regulation. Check out this informative article: buff.ly/3R1Ahbi #ILC2 #asthma '