CHIRAL CA-TALYSIS: The problem with chiral Ca catalysts are the long, highly ionic Ca-ligand bonds. This leads to rapid ligand exchange which spoils any enantioselectivity! We thought we had a solution but nature is smarter…. #maingroupchemistry See: pubs.rsc.org/en/content/art…
Controlling Enantioselectivity and Diastereoselectivity in Radical Cascade Cyclization via Co(II)-Based Metalloradical Catalysis (MRC) J. Am. Chem. Soc. doi.org/10.1021/jacs.1…
How can one achieve high enantioselectivity (∆∆G‡=2.1 kcal/mol) in a nearly barrierless reaction (∆G‡<3 kcal/mol)? With Melanie Blackburn, I'm excited to share new work addressing this question in the context of protio-semipinacol rearrangements: chemrxiv.org/engage/chemrxi…
Delighted to share our recent progress Nankai University published in Angewandte Chemie. We report enantiopure conjugated corral-shaped hosts with exceptional binding affinity and enantioselectivity in water! Gratitude to my students, collaborators, and reviewers. onlinelibrary.wiley.com/doi/epdf/10.10…
Boosting Enantioselectivity of Chiral Molecular Catalysts with Supramolecular Metal–Organic Cages bit.ly/3v298tX
#chemistry #openaccess #science #chemtwitter
#ProcterPOW : Check out the Zuo group's recent paper in Science – a single chiral Ti-catalyst and light facilitates the deracemization of alcohols by the combo of radical-mediated C-C bond cleavage and reconstruction resulting in high enantioselectivity.
Per-Ola Norrby Per-Ola Norrby, peonor@{mstdn|bsky}.social talking about enantioselectivity and the importance of conformers to get accurate transition state (ensembles). #AstraZeneca
Polarity inversion of conjugate acceptors. Not once, but twice! New route to full substituted olefins. Enantioselectivity (sometimes :)). Two C-C bonds. Polycyclic products. Congrats to Xuan and team. Angewandte Chemie Martin Breugst #accepted onlinelibrary.wiley.com/doi/10.1002/an…
Isolation of Cationic η3-Allenylnickel(II) Key Intermediate Complexes: Origins of Enantioselectivity and Regioselectivity in Nickel(0)-Catalyzed Asymmetric Propargylic Substitutions
J. Am. Chem. Soc. #Chemistry #Chemed #Science #TechnologyNews #news #technology
pubs.acs.org/doi/10.1021/ja…
Day 1 (Italy): #mechanochemistry workshop organised by COST Action CA18112 @mechsustind. Now Radovan Sebesta talking about enantioselectivity in a ball-mill. EuChemS EYCN Beyond Benign
Some of the secrets behind the performance and enantioselectivity of cyclopropanations with the NHPI-DA / Ru-Pheox tandem revealed! Check the full paper by Matteo Costantini, Ferran Planas Padrós (Himo group) and Marc Montesinos!! pubs.acs.org/doi/10.1021/ac…
Excellent defense by Ziyun Zhang of her PhD Thesis supervised by Laura Falivene and Luigi Cavallo of KAUST CATALYSIS CENTER (KCC) entitled 'Understanding and Engineering Enantioselectivity in asymmetric catalysis'. Honored to be member of the Evaluation Commitee.
Leveraging the Stereochemical Complexity of Octahedral Diastereomeric-at-Metal Catalysts to Unlock Regio-, Diastereo-, and Enantioselectivity in Alcohol-Mediated C–C Couplings via Hydrogen Transfer
J. Am. Chem. Soc. #Chemistry #Chemed #Science #Technology #News
pubs.acs.org/doi/10.1021/ja…
Interested in how machine learning partnered with innovative chemistry can iteratively drive improvement in catalyst enantioselectivity? Check out this Organic Process Research & Development contribution from #merckchemistry and the Denmark lab on phase-transfer catalysis. fal.cn/3jVaW
