Eosinophils โอ๊ย!สิโนฟิ่ว
( gornkun , กรกุน , 💖💚 )
*for entertainment only

Subepidermal bulla with eosinophils. DIF positive for C3 and IgG along the base of the epidermis (dermal-epidermal junction) in a linear pattern. The findings are consistent with bullous pemphigoid.

High levels of platelets, eosinophils, and monocytes in my blood and they still don’t know what it is…I’m home now and just want an answer 😔

The morphology is characterized by a triad of 1. Polymorphous cell infiltrate (plasma cells, histiocyte, eosinophils and the clear neoplastic T cells)
2. Follicular dendritic cell hyperplasia and
3. High endothelial venule proliferation 3/

Eosinophils are an important part of the immune system, and are named because of the characteristic stain (eosin) that gives them a reddish (magenta) color under a microscope.
#eosinophils #magenta #EosAware

In East london of south Africa, everyone joked I must have had a tapeworm or parasite after visiting coffee bay, I was eating like a pig. Considering this is at least my second year with batshit insane levels of eosinophils. They may have been right

More evidence on the role of eosinophils in #CVD : Dou et al. show how hematopoietic LNK deficiency triggers atherothrombosis through dysregulated JAK/STAT signaling and downstream #NETosis and #EETosis . Beautiful cover of today's Blood Journal! Check out our editorial inside:

$CRVS showed patient in #PTCL trial w/ #ITK inhibitor #soquelitinib reduced IL-5 and eosinophils by 95% matching Mepolizumab $GSK, Reslizumab $TEVA, Benralizumab $AZN results #asthma

BUT soqeulitinib is ORAL and ALSO stops #Th2 , #Th17 , IL-4, IL-9, IL-13, IL-17A, IL-21, IL-22!!

Eosinophils promote arterial thrombosis in hematopoietic LNK deficiency. ow.ly/xkmB50RooPt #thrombosisandhemostasis #phagocytesgranulocytesandmyelopoiesis

Blood Eosinophils in Chronic Obstructive Pulmonary Disease: Is There Enough Evidence?

Find out more by registering today: touchrespiratory.com/your-free-10-m…

Lower sputum neutrophils, correlated w/lower exacerbations (very stat-sig)- MOA validation

Papillion-Lefevre Syndrone (DPP1 deficiency) shows POC - can't make NETs

So, if no dose-response - likely not neutrophils (eg. eosinophils, 20-30%) driving exacerbations.

The percentage of peripheral eosinophils as a sensitive marker for differentiating FIGO grade in endometrial adenocarcinomas

You can see the free full text of the research by Serkan Akış et al.

Link : cms.jtgga.org/Uploads/Articl…

Eosinophils are a type of white blood cell. They are essential in the body’s immune response, as they contain proteins and other substances that can kill, destroy, or deactivate bacteria and other pathogens. ter.li/0mz8vl

Glucocorticoid-induced TNF receptor family–related protein functions as a costimulatory molecule for murine eosinophils. Learn more in this #JLB article by Narita and others.
buff.ly/4anvLuM

Complementary methods for the study of interactions between eosinophils and cancer cells. biorxiv.org/content/10.110…

See here how TrackMate-based label-free cell tracking & imaging by Acoustic focusing flowcytometry are coupled to finely detect immune vs tumor cell interactions.

Complementary methods for the study of interactions between eosinophils and cancer cells. biorxiv.org/cgi/content/sh… #biorxiv_cancer

Part 4. Few specific cytologic studies. Some warn about the similarities with Hodgkin's. Reasonable, dendritic cells can be large, eosinophils numerous and the background reactive.
Think on it when face to a dendritic/histiocytic-rich lesion. Thanks!!
karger.com/acy/article-ab…

Effect of disodium cromoglycate on activation of human eosinophils and neutrophils following reversed (anti-IgE) anaphylaxis eurekamag.com/research/039/9…

Allergic rxn so eosinophils will be raised.