Very interesting poster from UC San Francisco & University of Hawaii at Manoa on #LongCovid :

SARS-CoV-2 infects hematopoietic stem cells, which is proposed as the root cause of Long COVID.

croiconference.org/wp-content/upl…

Accelerated Hematopoietic Stem Cell Aging in Space biorxiv.org/content/10.110…

【CMV infection risk: Solid organ transplant vs Hematopoietic stem cell transplant】

Let's understand D+/R- being the highest risk in SOT vs D-/R+ in HSCT!

Level: Intermediate

#IDMedEd #IDFellow #TxID #Cytomegalovirus

Wow Caroline Sands knocked it out of the park on her qualifying exam! Cool work on p bodies and hematopoietic stem cells. Congrats!

Of 30 patients with severe #SickleCellDisease who were treated with gene-edited autologous hematopoietic stem and progenitor cells, 29 were free from vaso-occlusive crises for at least 12 consecutive months. Read the full CLIMB SCD-121 study results: nej.md/3UvzPDT

Rejuvenation Machine (Step 1) 🤩

Preserve annually 4 stem cell types via cryotherapy:

Endothelial, Mesenchymal, Pericyte, Hematopoietic.

Thaw later, inject younger cells to regenerate venous system, replacing and eliminating older cells. To get younger, year by year. 🥂

Blood cells originate from hematopoietic stem cells (HSCs) found in the bone marrow. These HSCs possess the remarkable ability to differentiate into all types of blood cells. As they divide, HSCs give rise to multipotent progenitor cells, which in turn differentiate into…

New paper out in Advanced Sci News with the Leach Lab and the Simon Lab focusing on biomaterials engineering for the transfer of #Hematopoietic #StemCells and their differentiation into #Neutrophils to promote the resolution of bacterial infections!
tinyurl.com/24t6f6fu

🔴 Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A 2024 Scientific Statement From the AHA #openAccess

ahajournals.org/doi/10.1161/CI…
#Cardiology #cardiotwitter #CardioEd #medical #medicine

☕️ My read for the weekend!
As usual, in this issue too, you ‘ll find excellent science in diverse cell biology areas!
👑Bonus for my #stemcell / #devbio friends: #HydrostaticPressure in development; #hematopoietic #aging ; #mechanobiology of #organogenesis

nature.com/ncb/volumes/26…

5/18/23:
'Although the lifespan of circulating monocytes is on the order of days, imprinting of hematopoietic progenitor cells in the bone marrow... might explain these long-lived changes in the circulating monocyte compartment.'
elifesciences.org/articles/86014

🎉Finally out🎉

Management of adult patients with CMML undergoing allogeneic hematopoietic cell transplant: recommendations from ⁦The EBMT⁩

⁦Blood Journal⁩ #mpnsm ashpublications.org/blood/article/…

With a new NIDDK grant, Drs. Kapur & Tran will investigate why hematopoietic stem cells respond well in hypoxia, a low-oxygen environment in the bone marrow. Their discoveries could influence treatment options for bone marrow failure & rare blood diseases. medicine.iu.edu/news/2024/04/h…

Congrats to EinsteinCellBio post-doc Yun-Ruei Christine Kao and Britta Will for discovering an iron-mediated, non-invasive rejuvenation strategy to preserve hematopoietic stem cell youth. Check out their recent Cell Stem Cell publication here: dlvr.it/T36Hpj

Our new study led by super postdoc fellow Mengmeng Mengmeng Jin

A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimers Disease
biorxiv.org/content/10.110…

Throwback to our illustration for Robert Signer : How do stem cells stay fit?

🧬 'Hsf1 promotes hematopoietic stem cell fitness & proteostasis in response to ex vivo culture stress and aging.'
sciencedirect.com/science/articl…
#Sciart #DrawImpacts

Outcomes with Allogeneic Hematopoietic Stem Cell Transplantation in TP53-mutated MDS sciencedirect.com/science/articl…

🚨It's the CD8 T cell RESPONSE to bone marrow reservoirs that causes Long Covid. This is important because not everyone has CD8 in the marrow to respond to persistent antigen. Marrow CD8's shut down hematopoietic stem cell renewal impairing blood/immune function. Please, share.🚨

Honored to serve as an editor of “Metabolic control in hematopoietic homeostasis,” a special issue of
Exp Hem. Great thanks to all authors, including Nina Cabezas-Wallscheid Katherine King MDPhD Drs.
Nillson, Suda & Filippi Daphna Nachmani, and ISEH for their help. sciencedirect.com/science/articl…

Adoptive cellular therapy after hematopoietic stem cell transplantation

onlinelibrary.wiley.com/doi/epdf/10.10…