My *least* favorite bone marrow is one that comes with the clinical history of 'r/o HLH'. #Hemophagocytosis is neither sensitive nor specific for HLH. It is one of 8 criteria, and you need 5 to diagnose. What’s your least favorite? #hemepath #pathology
Subcutaneous panniculitis like T-cell lymphoma. Atypical lymphocytes rim adipocytes. Hemophagocytosis (beanbag) of red cells and other inflammatory cells. TCR a/b, CD8+, cytotoxic markers. Immuno here is TIA-1. #dermatology #Dermpath #pathology #lymphoma #hematology #medicine
Hemophagocytosis elicited by a marrow macrophage in acute leukemia.
#pathology #hematology #hemepath #hemophagocytosis #leukemia
Hemophagocytic lymphohistiocytosis #HLH - By Nicolas Taar (Fellow in Infectious Diseases, Lille, France) and Noemie Prudhomme (Fellow in Geriatry, Lille, France) #hemophagocytosis #lymphohistiocytosis #InternistAcademy
INTERESTING CASE:
Patient with Respiratory Failure :
✅(1) Fever>38.5
✅(2) Hypertriglyceridemia(>900)
✅(3) Elevated ferritin (>11,000)
✅(4) CD25 (3500)
✅(5) Bone Aspirate: Hemophagocytosis
👉✅✅ Hemophagocytic Lymphohistiocytosis (HLH) #hemepath #PathTwitter #hematology
#morningcytologyrounds at Marien Hospital #88
A lady with WBC 350/µL, Hgb 7.2 g/dL and PLT 11.000/µL was admitted for diagnosis. LDH 1298 U/L, INR 1.5, PTT 49 sec., Fibrinogen 100 mg/dL. Ferritin 90.000 ng/mL. She is severely ill. Bone marrow cytology reveals hemophagocytosis /1.
