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A major question in the field of hiPSC cardiac differentiation is whether we can generate cells from the left and right ventricles of the heart (Important implications for modeling single ventricle congenital heart defects) 2/8

Congratulations to James Burford, researcher in the Morton Lab at the University of Southern California, for receiving an Axion Travel Award to #ISSCR2023 !

James will present his team's work investigating the impact of mutations in the EXOSC3 gene on the development of…

Importantly, we observed a FHF-like progenitor population during hiPSC differentiation that emerged from an early ISL1+ cardiac progenitor, providing a unique view into the emergence of the FHF in a human model system. 7/8

If you're heading to #ISSCR2023 , make sure to stop by booth 932 and visit our posters. Our scientists are ready to chat with you on how we can support your CNS drug discovery with our hiPSC-based technology platforms and disease modeling capabilities.
neucyte.com/isscr2023

Very excited for the publication of our study in StemCellReports on the nutritional requirements of hiPSC. This work resulted in the ultra simple formula BMEM. Less is more!

cell.com/stem-cell-repo…

By computationally mapping differentiation trajectories in our scRNA-seq data, we identified genetic signatures during hiPSC development that matched those of murine FHF differentiation into myocardial and epicardial lineages. 6/8

Excited to share our work on FHF lineage tracing in human iPSCs & the generation of hiPSC-derived left ventricular CMs! A special thanks to all the co-authors for their contributions. Sean M Wu Soah Lee Tahmina Samad, M.D. Rasmus O. Bak See ⬇️ for a🧵 elifesciences.org/articles/80075

Using single cell RNA seq with oligonucleotide-based sample multiplexing, we extensively profiled differentiating hiPSCs across 12 timepoints in two independent iPSC lines to construct a high resolution map of hiPSC cardiac differentiations 4/8

Our #CellLineOfTheWeek is the CAAX domain of K-Ras (plasma membrane)! 🧫

Our hiPSC lines & plasmids – fluorescently-tagged to illuminate structures – are openly available to drive discovery: bit.ly/AccessAllenCel…

📦 Distributed by Coriell Institute & Addgene.

#OpenScience

Congratulations, Jim! New direction for my lab, hiPSC-derived brain organoid models of NDDs, exciting stuff! Shout out to Nina Barr , graduate student leading this project - great work! #ISSCR2023

I'm thrilled to be sharing my work on the transcriptomic profiling of hiPSC-derived neuronal models for 7q11.23 disorders at #ESHG2023
Come and check it!

Sometimes it takes a village!

🧿Combining #iPSC villages and single cell #RNASeq offers a method for upscaling cultures

🧿🦘Aus multi-site study 🏥🏩🏥 feat. 🫀CM diffs #CardioTwitter

nature.com/articles/s4146…

What was the experimental design?

The experimental design was to collect samples of the lines cultured separately and, after four days, cultured in a village at three independent sites. In addition, they compared fresh and cryopreserved uni-culture...
nature.com/articles/s4146…

👗 Off-the-shelf #CellTherapy !

Dr. Yanhong Shi's team at City of Hope developed hypoimmunogenic #hiPSC -derived oligodendrocyte progenitor cells as an off-the-shelf cell therapy for #myelin disorders.

👇 Check out its therapeutic versatility!
Advanced Sci News | bit.ly/42vGfDy

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Validating the pharmacogenomics of doxorubicin-induced cardiotoxicity by Dr. Paul Burridge #PGRN2023

Congrats 2 Francisco Francisco Galdos, PhD on his newly accepted manuscript eLife - the journal on FHF lineage tracing in human iPSCs & the generation of hiPSC-derived left ventricular CMs. 🙏to contributions by many co-authors Soah Lee William Goodyer, MD/PhD @Tahmina_Sam2 & others. doi.org/10.7554/eLife.…

Join us in the next National Stem Cell Conversations, Weds 7 June at 11am AEDT. Exciting talk on neural networks with Ronald Buijsen from #LeidenUniversityMedicalCentre and Brett J. Kagan from Cortical Labs

Email us to join the Conversation 👉 [email protected]

Unexpectedly, both our reporter system and scRNA-seq data revealed a predominance of TBX5-lineage positive ventricular CMs when using a standard small molecular WNT modulation protocol for hiPSC cardiac differentiation. 5/8

To answer this, we developed a combined TBX5/MYL2 lineage tracing reporter system in hiPSCs to determine whether hiPSC cardiac diffs generate cells from the first heart field (FHF) and second heart field (SHF) lineages which give rise to the LV and RV, respectively. 3/8

We're heading to ISSCR 2023 to discuss our work using human iPSCs to build better disease models, and present our microglia data. Make sure to speak to our representatives, or get in touch here:

hubs.la/Q01SXJh30

#ISSCR2023 #iPSCs #StemCells #DrugDiscovery #hiPSC

Awesome talk by Dr. Paul Burridge, using patient-specific hiPSC-derived cardiomyocytes to validate genes from GWAS for Doxorubicin-Induced Cardiotoxicity. #CardioResearch sciencedirect.com/science/articl…
sciencedirect.com/science/articl…

Thanks Australasian Society for Stem Cell Research for the opportunity to present our SCA1 hiPSC work.

Also great to see the work of Cortical Labs. I did not know that neurons in a dish can play pong. Great work and I am looking forward to hearing the follow up studies!

Drs. Menglu Li, Katsumasa Fujita & colleagues at Research@OU (ResOU) and beyond demonstrated that #RamanImaging provides a promising tool for both quality control of hiPSC-derived #hepatocytes and #hepatotoxicity screening.

🔗 Analytical Chemistry: bit.ly/45UR0lW