A single-chain CD38 T-cell engager targets CD38-negative LSCs activated by IFN-γ and induces CD38 expression on AML blasts. ow.ly/GNLx50Rjhms #immunobiologyandimmunotherapy #hematopoiesisandstemcells #myeloidneoplasia
The novel EHA/EBMT grading of ICAHT closely reflects the extent of hematological toxicity following BCMA- and CD19-directed CAR-T therapy. ow.ly/f11U50RyOJ2 #immunobiologyandimmunotherapy #hematopoiesisandstemcells #lymphoidneoplasia
Cryo-EM structure of the type I antiphospholipid antibody POmAb bound to the region R90-Y93 of kringle-1 of prothrombin is described. ow.ly/HwQu50RARX6 #thrombosisandhemostasis #immunobiologyandimmunotherapy
T-cell help in the TME enhances rituximab-mediated NK-cell viability, CD16 and CD25 expression, and antitumor response. ow.ly/7z1V50RvWwl #immunobiologyandimmunotherapy #clinicaltrialsandobservations #lymphoidneoplasia
Expanding the HLA-I–restricted MiHA repertoire by 81 new antigens reveals that MiHAs are often recurrently targeted in multiple patients. ow.ly/G4KJ50RvVjc #transplantation #immunobiologyandimmunotherapy
Maintenance therapy for early loss of B-cell aplasia after anti-CD19 CAR T-cell therapy
ow.ly/bq3m50RmqWc #immunobiologyandimmunotherapy #lymphoidneoplasia
The NK receptor ligands, PVR and B7-H6, are required for AML cell recognition and immunological synapse formation with DOT cells. ow.ly/wvKI50Reqmw #immunobiologyandimmunotherapy #myeloidneoplasia
Combining circulating absolute monocyte count and a 4-gene monocyte signature at leukapheresis predicts PFS of LBCL receiving CAR T cells. ow.ly/nEKc50RyQvo #lymphoidneoplasia #immunobiologyandimmunotherapy
IFN-γ and CD38 in AML: a T-cell engagement made in heaven?
ow.ly/ZcEM50Rjiob #immunobiologyandimmunotherapy
Immunotherapies can be studied in a syngeneic or an allogeneic setting after stem cell transplant. ow.ly/tflQ50RyOSU #immunobiologyandimmunotherapy #lymphoidneoplasia
Severe ICAHT was associated with transfusion use, an increased rate of severe infections and adverse treatment outcomes with high NRM. ow.ly/6okA50Rn4bz #immunobiologyandimmunotherapy #hematopoiesisandstemcells #lymphoidneoplasia
Monocytes depletion from apheresis products could result in improved outcome of patients with R/R LBCL receiving CD19–directed CAR T cells. ow.ly/HLHO50Rn45A #lymphoidneoplasia #immunobiologyandimmunotherapy
Treg depletion during SCM expands polyfunctional effector T cells in mobilized grafts and enhances antimyeloma immunity after ASCT. ow.ly/syjV50RjakL #transplantation #immunobiologyandimmunotherapy
Is estimated exposure an accurate surrogate for measured fludarabine levels in patients with CAR T-cell therapy?
ow.ly/qqIB50RG5P6 #commentary #immunobiologyandimmunotherapy #lymphoidneoplasia
The monovalent albumin fusion protein showed no AEs, whereas the Fc-impaired 1-armed antibody induced minor changes in body temperature. ow.ly/UCXn50Rn4gP #immunobiologyandimmunotherapy
Human FcγRIII monovalent blocking as a 1-armed antibody or albumin fusion protein are effective in a humanized model of ITP. ow.ly/2rMV50RyOPa #immunobiologyandimmunotherapy
Regression of smoldering myeloma with treatment of Gaucher disease
ow.ly/6IFe50RbGa7 #immunobiologyandimmunotherapy #lymphoidneoplasia
We present a novel immunotherapy platform for hematological cancers that exploits fundamental metabolic dysregulation of cancer cells. ow.ly/e6ro50RbLTK #immunobiologyandimmunotherapy #myeloidneoplasia
