Autocrine activation of P2X7 receptor #IonChannels mediates catecholamine secretion in chromaffin cells
buff.ly/4dnjpF9
A triple cysteine motif as major determinant of the modulation of neuronal KV7 #Ionchannels by the paracetamol metabolite N‐acetyl‐p‐benzo quinone imine - Ray - British Journal of Pharmacology British Journal of Pharmacology (BJP)
buff.ly/3y5QMMg
Steve Jenkinson is looking forward to hearing about the latest work of the HESI Cardiac Safety Committee at this workshop next week.
Steve is attending the meeting virtually but you can contact Steve here: hubs.la/Q02vJj270
#drugdiscovery #ionchannels #cardiacsafety
The QPatch® from Sophion Bioscience A/S is a fully automated #patchclamp system designed to perform parallel gigaseal #ionchannel recordings of 16 or 48 cells.
#drugdiscovery #PatchClamp #planarpatch #ephys #electrophysiology #QPatch #automatedpatchclamp #IonChannels
Toxins!! Such an interesting reading
From foes to ion channel targeting and drug discovery 🧪
With cutting-edge tech we are a step closer to new therapeutic opportunities. #DrugDiscovery #Toxins #ionchannels
link.springer.com/chapter/10.100…
Are you a researcher interested in the #proteome ? Learn more about a series of articles highlighting resources developed by our Illuminating the DruggableGenome program to facilitate research on #gpcrs #kinases & #ionchannels : go.nih.gov/IDG-PaperPacka…
GWAS: Upregulated GIRK2 #IonChannels Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons | Journal of Neuroscience buff.ly/4b5L778
£€$¥
Mutation in pore-helix modulates interplay between filter gate and Ba²⁺ block in a Kcv channel pore. A new study from Noel Tewes, Oliver Rauh and colleagues TU Darmstadt: hubs.la/Q02tNwm50
#Biophysics #MembraneTransport #MolecularPhysiology #ProteinStructure #IonChannels
Calcium‐sensing receptor regulates Kv7 #IonChannels via Gi/o protein signalling and modulates excitability of human induced pluripotent stem cell‐derived nociceptive‐like neurons - Chuinsiri - British Journal of Pharmacology #OpenAccess buff.ly/4aJ7VtO
British Journal of Pharmacology (BJP)
Temperature modulates PVN pre-sympathetic neurones via transient receptor potential #ionchannels buff.ly/4bhnskl
Are you a researcher interested in the #proteome ? Learn more about a series of articles highlighting resources developed by our Illuminating the DruggableGenome program to facilitate research on #gpcrs #kinases & #ionchannels : go.nih.gov/E8cbSGH
In JGenPhysiol, Tewes, Rauh et al. TU Darmstadt use a simple K⁺ channel pore to examine filter gating. Voltage-dependent closings in pore-helix mutants can be explained by an elevated sensitivity to block by trace contaminations of Ba²⁺. hubs.la/Q02tPMqS0
#IonChannels
📣 Call for Papers 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. ➡️ hubs.ly/Q02dxrCm0
#IonChannels
Are you striving for increased diversity and efficiencies in screening and target identification?
Combine your libraries with the power of our specialist #ionchannels and high-throughput #screening and hit-finding expertise:
hubs.ly/Q02tKVHY0
#cro #drugdiscovery
Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders. doi.org/10.1093/brain/… This paper was the result of an extensive collaboration between investigators at Northwestern Feinberg School of Medicine and FamilieSCN2A. #SCN2A #ionchannels #epilepsy #Autism
🎙️Derek Leishman, Eli Lilly, will focus on the opportunities a sponsor now has available to increase the efficiency and effectiveness of QTc assessment by leveraging the ICH S7B core assays.
🔗 hubs.la/Q02tT-f20
#drugdiscovery #ionchannels #cardiacsafety #cardiacrisk
