Pfffiufff gave my first talk on #immunometabolism today 😅 at the International Union of Immunological Societies course, and fell in love with #itaconate while preparing it!

The course is fun and i am learning on #leukocytes I don’t work on.

+ #Oaxaca perks!

In a sick cell, the usual Krebs cycle (green pathway) that produces ATP (purple lines) is bypassed by what they call the “itaconate shunt” (blue pathway). This is initiated by an enzyme called CAD

A clearer diagram of the itaconate shunt from this presentation by Ron Davis: youtu.be/7inKF32vtl8?si…

How does this itaconate shunt get activated? In response to a trigger (usually viral infection), interferon-alpha gets produced, to stimulate immune response. This initiates JAK-STAT signalling, which results in the upregulation of CAD, the key enzyme that initiates the shunt

Citrate, Itaconate, Isocitrate

Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells #immunometabolism
cell.com/cell-metabolis…

Had a great time at the International Cytokine & Interferon Society (ICIS) presenting my PhD work from the Luke O’Neill lab on itaconate and interferons 🇬🇷 #immunometabolism #cytokines2023

Excited to share our article is live on the Journal of Immunology! We explore an itaconate derivative's impact on eosinophil development & airway inflammation. Huge thanks to the incredibleteam and my PhD supervisor Luke O'Neill! TCD TBSI 📚 #Research #Immunology

I’m at BSI Congress & Events! Join me at Poster 259 to chat all things itaconate and type-I interferon #BSI23

There’s guys my age living their lives traveling, partying, working etc, while I spend my free time in bed researching shit like mitochondrial respiration and the itaconate pathway. Me and him Nah we are not the same

Harvesting after a long season 🥵 #hojeeutonojenta
These are my main authorships of the season:

1) Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in MODCs sciencedirect.com/science/articl…

Always great to kick off the New Year with a new paper from our lab, thanks to Dawn!
Itaconate and citrate releasing polymer attenuates foreign body respon... sciencedirect.com/science/articl…

Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells dlvr.it/T3pKK2

Itaconate boosts malaria via induction of PD-L1 dlvr.it/T3x098

Excited to share that 'Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella' is now available in Nature Microbiology!
nature.com/articles/s4156…

insult mediated complex chronic conditions: the itaconate shunt. This includes #LongCovid #VaccineInjuries #Lyme etc

These diseases are so horrific, people keep dying by suicide. Please help us.

Science doesn’t take time, it takes money.
Share 🙏🏻

openmedicinefoundation.crowdchange.co/34134

The Luke O’Neill Lab are in BSI Congress & Events
Come see our posters regarding all things Itaconate & derivatives from
Emily Day (P-258), Maureen Yin (P-133), Yukun Min 闵煜昆 (257) and myself (P-259)!

Christian Peace will present his work on Wednesday at 11:45 in Hall2A!
#BSI23

ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis dlvr.it/T3g0NQ

🚨Last weeks #immunometabolism discoveries Bims: Biomed News 👇👇👇

biomed.news/bims-imicid/20…

Highlights
I) Lung DC metabolism underlies susceptibility to viral infection in diabetes
II) Oleic acid availability regulates Treg diff
III) Itaconate suppresses atherosclerosis via NRF2

Recent Dr. Ron Davis talk is released. Cell energy depletion (ATP) as a result of itaconate shunting is discussed. Itaconite shunting may be modulated by JAK-STAT inhibitors and/or CAD inhibitors. Looking at existing drugs for inhibitors to CAD.